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Microbiol."],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    Infectious bursal disease virus (IBDV) is a major cause of immunosuppression in chickens that has been shown to affect influenza A virus (avian influenza virus (AIV)) pathogenicity and shedding patterns. In this study, we compared the shedding of a low passage duck origin AIV in two groups of specific- pathogen free chickens: one group that was IBDV-inoculated and one sham-inoculated group. At 3 weeks of age, the birds were divided and intranasally given one of three doses (10\n                    <jats:sup>2<\/jats:sup>\n                    , 10\n                    <jats:sup>3<\/jats:sup>\n                    , 10\n                    <jats:sup>5<\/jats:sup>\n                    ) of A\/mallard\/OH\/421\/1987 (H7N8) low pathogenicity AIV. Although the bursae of the IBDV-infected chicks had higher lesion scores, the damage was minimal. We observed that this low IBDV exposure increased resistance to AIV challenge. Uninoculated contacts co-housed with the treatment groups given 10\n                    <jats:sup>5<\/jats:sup>\n                    AIV became infected. Additionally, chicks shedding approximately 10\n                    <jats:sup>3\u20134<\/jats:sup>\n                    EID\n                    <jats:sub>50<\/jats:sub>\n                    \/ml AIV (C\n                    <jats:sub>T<\/jats:sub>\n                    of 33 or less) transmitted virus to cage mates. These findings demonstrate that the impacts of immunosuppressive agents on AIV challenge may vary, based on a number of confounding factors.\n                  <\/jats:p>","DOI":"10.1139\/cjm-2025-0208","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T21:38:44Z","timestamp":1781041124000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating how infectious bursal disease virus influences influenza A virus transmission in chickens"],"prefix":"10.1139","volume":"72","author":[{"given":"P.","family":"Bonney","sequence":"first","affiliation":[{"name":"University of Minnesota","place":["St. Paul, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.R.","family":"Culhane","sequence":"additional","affiliation":[{"name":"University of Minnesota","place":["St. Paul, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Broadbent","sequence":"additional","affiliation":[{"name":"University of Maryland","place":["College Park, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Flores-Figueroa","sequence":"additional","affiliation":[{"name":"Veterinary Research Laboratory at the Minnesota Research and Outreach Center","place":["Willmar, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Munoz-Aguayo","sequence":"additional","affiliation":[{"name":"Veterinary Research Laboratory at the Minnesota Research and Outreach Center","place":["Willmar, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristelle","family":"Mendoza","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine","place":["St. Paul, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3656-1865","authenticated-orcid":false,"given":"C.J.","family":"Cardona","sequence":"additional","affiliation":[{"name":"University of Minnesota","place":["St. Paul, USA"]},{"name":"Veterinary Research Laboratory at the Minnesota Research and Outreach Center","place":["Willmar, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"refg2\/ref2","first-page":"1","volume":"35","author":"Christensen R.H.B.","year":"2018","journal-title":"J. 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