{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T20:11:22Z","timestamp":1649016682288},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[1953,8,1]],"date-time":"1953-08-01T00:00:00Z","timestamp":-518140800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Medical Sciences"],"published-print":{"date-parts":[[1953,8]]},"abstract":"<jats:p> Cholera vaccine prepared in a chemically defined fluid medium (containing tyrosine, asparagine, glycine, and inorganic salts) was compared antigenically in mice with vaccines prepared by standard methods. The mean LD<jats:sub>50<\/jats:sub> for normal mice was 108 \u00b1 9.1 V. comma of the strain employed for challenging. Both vaccines afforded a high degree of protection. Mice immunized with bivalent (Ogawa and Inaba) Standard vaccine had a mean LD<jats:sub>50<\/jats:sub> of 40.0 \u00b1 4.7 million V. comma. Mice protected by bivalent fluid-prepared vaccine had a mean LD<jats:sub>50<\/jats:sub> of 32.7 \u00b1 6.0 million V. comma. The difference is not statistically significant. Vaccines prepared in fluid medium were relatively unstable. <\/jats:p>","DOI":"10.1139\/cjms53-035","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T13:23:49Z","timestamp":1512393829000},"page":"338-342","source":"Crossref","is-referenced-by-count":0,"title":["THE ANTIGENICITY OF CHOLERA VACCINE PREPARED IN FLUID MEDIUM"],"prefix":"10.1139","volume":"31","author":[{"given":"L. E.","family":"Ranta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula M.","family":"McCreery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/cjms53-035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T04:17:48Z","timestamp":1578284268000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/cjms53-035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1953,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1953,8]]}},"alternative-id":["10.1139\/cjms53-035"],"URL":"https:\/\/doi.org\/10.1139\/cjms53-035","relation":{},"ISSN":["0316-4403"],"issn-type":[{"value":"0316-4403","type":"print"}],"subject":[],"published":{"date-parts":[[1953,8]]}}}