{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:21:52Z","timestamp":1768872112197,"version":"3.49.0"},"reference-count":20,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>The objective of this study was to evaluate the possible benefits of coenzyme Q<jats:sub>10<\/jats:sub>and selenium supplementation administered to patients with statin-associated myopathy (SAM). Sixty eligible patients entered the pilot study. Laboratory examination (CoQ10, selenium, creatin kinase) and intensity of SAM (visual scale) were performed at baseline, after 1 month, and at the end of study at month 3. Plasma levels of CoQ10 increased from 0.81 \u00b1 0.39 to 3.31 \u00b1 1.72 \u03bcmol\/L in the active group of patients treated by CoQ10, compared with the placebo (p = 0.001). Also, the symptoms of SAM significantly improved in the active group (p &lt; 0.001): the intensity of muscle pain decreased from 6.7 \u00b1 1.72 to 3.2 \u00b1 2.1 (p &lt; 0.01, \u201353.4 \u00b1 28.2%); muscle weakness decreased from 7.0 \u00b1 1.63 to 2.8 \u00b1 2.34 (p &lt; 0.01, \u201360 \u00b1 24.0%); muscle cramps decreased from 5.33 \u00b1 2.06 to 1.86 \u00b1 2.42, p &lt; 0.01, \u201365 \u00b1 28%); tiredness decreased from the initial 6.7 \u00b1 1.34 to 1.2 \u00b1 1.32 (p &lt; 0.01, \u201382 \u00b1 22%). We did not observe any significant changes in the placebo group. In conclusion, supplementation of statin-treated patients with CoQ10 resulted in a decrease in the symptoms of SAM, both in absolute numbers and intensity. Additional selenium supplementation was not associated with any statistically significant decrease of SAM. However, it is not possible to draw any definite conclusions, even though this study was carried out in double-blind fashion, because it involved a small number of patients.<\/jats:p>","DOI":"10.1139\/cjpp-2012-0118","type":"journal-article","created":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T18:58:02Z","timestamp":1354733882000},"page":"165-170","source":"Crossref","is-referenced-by-count":68,"title":["Coenzyme Q<sub>10<\/sub>and selenium in statin-associated myopathy treatment"],"prefix":"10.1139","volume":"91","author":[{"given":"Jan","family":"Fedacko","sequence":"first","affiliation":[{"name":"Pavol Jozef Safarik University, 1st Department of Internal Medicine, Centre of Excellency for Atherosclerosis Research, Trieda SNP 1, 041 90 Kosice, Slovakia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Pella","sequence":"additional","affiliation":[{"name":"Pavol Jozef Safarik University, 1st Department of Internal Medicine, Centre of Excellency for Atherosclerosis Research, Trieda SNP 1, 041 90 Kosice, Slovakia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Fedackova","sequence":"additional","affiliation":[{"name":"Pavol Jozef Safarik University, Department of Experimental Medicine, Kosice, Slovakia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osmo","family":"H\u00e4nninen","sequence":"additional","affiliation":[{"name":"University of Kuopio, Department of Physiology, Kuopio, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petri","family":"Tuomainen","sequence":"additional","affiliation":[{"name":"University of Kuopio, Department of Cardiology, Kuopio, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Jarcuska","sequence":"additional","affiliation":[{"name":"Pavol Jozef Safarik University, 1st Department of Internal Medicine, Centre of Excellency for Atherosclerosis Research, Trieda SNP 1, 041 90 Kosice, Slovakia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Lopuchovsky","sequence":"additional","affiliation":[{"name":"Pavol Jozef Safarik University, 1st Department of Internal Medicine, Centre of Excellency for Atherosclerosis Research, Trieda SNP 1, 041 90 Kosice, Slovakia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Jedlickova","sequence":"additional","affiliation":[{"name":"Pavol Jozef Safarik University, 1st Department of Internal Medicine, Centre of Excellency for Atherosclerosis Research, Trieda SNP 1, 041 90 Kosice, Slovakia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Merkovska","sequence":"additional","affiliation":[{"name":"Pavol Jozef Safarik University, 1st Department of Internal Medicine, Centre of Excellency for Atherosclerosis Research, Trieda SNP 1, 041 90 Kosice, Slovakia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Paolo","family":"Littarru","sequence":"additional","affiliation":[{"name":"Marche Polytechnic University, Department of Odontostomatological and Clinical Sciences, Ancona, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533608314532"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-005-5686-z"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.3402\/fnr.v52i0.1642"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-005-6352-1"},{"key":"refg5\/ref5","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1080\/07315724.2001.10719063","volume":"20","author":"Crane F.L.","year":"2001","journal-title":"J. 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