{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:23:48Z","timestamp":1782861828975,"version":"3.54.5"},"reference-count":34,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p> The aim of this study was to evaluate the effects of exenatide on levels of serum adipocytokines and on \u03b2-cell function. The study was conducted between 2008 and 2012. After a run-in period with metformin, 174 patients with type-2 diabetes were randomly distributed to either a group receiving exenatide at 10 \u03bcg twice daily, or a group receiving the placebo, for 12 months. We evaluated body mass index (BMI), blood pressure, glycemic control, lipid profile, fasting plasma insulin (FPI), HOMA-IR, HOMA-\u03b2, fasting plasma proinsulin (FPPr), proinsulin : fasting plasma insulin ratio (Pr\/FPI ratio), C-peptide, glucagon, retinol binding protein-4 (RBP-4), visfatin, omentin-1, and microalbuminuria. We used ELISA methods to assess the various parameters. Patients also underwent a combined euglycemic-hyperinsulinemic and hyperglycemic clamp, with subsequent arginine stimulation. After 12 months, a combination of exenatide and metformin produced a better decrease in body mass, BMI, glycemic control, FPI, FPPr, FPPr\/FPI ratio, HOMA-IR, and glucagon level. Treatment with exenatide + metformin was superior to the placebo + metformin in increasing HOMA-\u03b2, C-peptide, and \u03b2-cell function. Significant negative correlations were found between M value, an index of insulin sensitivity, and measured adipocytokines. In conclusion, the combination of exenatide + metformin plays a role in improving some adipocytokine levels, and is better than metformin alone. The significant negative correlation between M value and measured adipocytokines is another confirmation of the positive effects linked to the improvement in insulin sensitivity. <\/jats:p>","DOI":"10.1139\/cjpp-2012-0300","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T06:44:26Z","timestamp":1366699466000},"page":"724-732","source":"Crossref","is-referenced-by-count":19,"title":["Effects of exenatide and metformin in combination on some adipocytokine levels: a comparison with metformin monotherapy"],"prefix":"10.1139","volume":"91","author":[{"given":"Giuseppe","family":"Derosa","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Piazzale Camillo Golgi 2, 27100 Pavia, Italy."},{"name":"Center for the Study of Endocrine \u2013 Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arrigo F.G.","family":"Cicero","sequence":"additional","affiliation":[{"name":"Aging and Kidney diseases, \u201cG. 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