{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T08:09:33Z","timestamp":1775981373831,"version":"3.50.1"},"reference-count":79,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>Cardiovascular disease (CVD) impacts the autonomic nervous system and cognitive functions related to activities of daily living, including driving an automobile. Although CVD has been linked to unsafe driving, mechanisms underlying this relationship remain elusive. The aim of this study was to examine the role of cognitive functions and the autonomic nervous system as potential mediators of driving performance. Nineteen individuals having recently suffered a cardiac event and 16 individuals with no history of CVD completed a simulated drive using a STISIM simulator to assess driving performance. Heart rate was recorded throughout testing using a Polar RS800CX heart rate monitor, and measures of executive, orienting, and alerting functions were obtained through the Attention Network Test. We used the Baron and Kenny analysis method to assess potential mediating effects of the relationship between CVD and driving performance. Executive function was the only potential mediator investigated to be associated with driving (p &lt; 0.01) and CVD (p &lt; 0.05); however, it did not appear to play a mediating role (p = 0.28). These results suggest that individuals with CVD exhibit decrements in complex cognitive tasks such as driving and that further research is needed to better understand the mechanisms underlying this relationship.<\/jats:p>","DOI":"10.1139\/cjpp-2012-0342","type":"journal-article","created":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T15:37:49Z","timestamp":1357227469000},"page":"346-352","source":"Crossref","is-referenced-by-count":5,"title":["Investigating the autonomic nervous system and cognitive functions as potential mediators of an association between cardiovascular disease and driving performance"],"prefix":"10.1139","volume":"91","author":[{"given":"Jeffrey","family":"Gaudet","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Sherbrooke, 2500, boul. de l'Universit\u00e9, Sherbrooke , J1K 2R1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu F.","family":"B\u00e9langer","sequence":"additional","affiliation":[{"name":"Centre de formation m\u00e9dicale du Nouveau-Brunswick, 18 avenue Antonine-Maillet, Moncton, NB E1A 3E9, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Corriveau","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Sherbrooke, 2500, boul. de l'Universit\u00e9, Sherbrooke , J1K 2R1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said","family":"Mekary","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Moncton, CEPS Louis-J. Robichaud, 18 avenue Antonine-Maillet, Moncton, NB E1A 3E9, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean","family":"Hay","sequence":"additional","affiliation":[{"name":"Nipissing University, 100 College Drive, Box 5002, North Bay, ON P1B 8L7, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Moncton, CEPS Louis-J. Robichaud, 18 avenue Antonine-Maillet, Moncton, NB E1A 3E9, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s1010-7940(02)00807-2"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2008.01713.x"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1037\/a0023835"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2004.07.008"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1076\/1380-3395(200010)22:5;1-9;FT686"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1630.2011.00963.x"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617702801345"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.51.6.1173"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1080\/15389580701670705"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.64.2.336"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0569-y"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1994.tb01500.x"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1037\/a0014888"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.11.008"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1162\/089892906775990606"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2007.19.1.69"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.24.2.221.993"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2007.03.022"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.1.9"},{"key":"refg21\/ref21","doi-asserted-by":"crossref","unstructured":"Dobbs, B.M. 2005. Medical conditions and driving: A review of the scientific literature (1960\u20132000). (Technical Report No. DOT HS 809 690). Department of Transportation, National Highway Traffic Safety Administration, Washington D.C.","DOI":"10.1037\/e729552011-001"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-2136(08)71801-1"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/59.6.P285"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1080\/87565641.2011.632459"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1162\/089892902317361886"},{"issue":"40","key":"refg26\/ref26","first-page":"1377","volume":"60","author":"Fang J.","year":"2011","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2005.09.027"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000218135.79476.9c"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.14.8301"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1111\/1469-8986.2004.00179.x"},{"key":"refg31\/ref31","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3256"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8760(03)00073-4"},{"key":"refg33\/ref33","doi-asserted-by":"publisher","DOI":"10.1080\/10615800802272251"},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03499.x"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2011.06.012"},{"key":"refg36\/ref36","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-817878"},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.5.981"},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.1159\/000264631"},{"key":"refg39\/ref39","first-page":"97","volume":"47","author":"Lane R.D.","year":"2001","journal-title":"Brain Cogn."},{"key":"refg40\/ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.07.056"},{"key":"refg41\/ref41","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507080467"},{"key":"refg42\/ref42","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.8.1274"},{"key":"refg43\/ref43","doi-asserted-by":"publisher","DOI":"10.1136\/ip.8.2.116"},{"key":"refg44\/ref44","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014868"},{"key":"refg45\/ref45","doi-asserted-by":"publisher","DOI":"10.1080\/09084280802644086"},{"key":"refg46\/ref46","doi-asserted-by":"publisher","DOI":"10.1080\/15389580801895244"},{"key":"refg47\/ref47","doi-asserted-by":"publisher","DOI":"10.1310\/tsr1401-98"},{"key":"refg48\/ref48","unstructured":"McArdle, W.D., Katch, F.I., and Katch, V.L. 2007. Exercise physiology: Energy, nutrition & human performance, 6th ed. Lippincott Williams & Wilkins."},{"key":"refg49\/ref49","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.5.424"},{"key":"refg50\/ref50","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0511(01)00112-0"},{"key":"refg51\/ref51","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/679345"},{"key":"refg52\/ref52","doi-asserted-by":"publisher","DOI":"10.1097\/00008483-199903000-00002"},{"key":"refg53\/ref53","doi-asserted-by":"crossref","unstructured":"Moses, Z.B., Luecken, L.J., and Eason, J.C. 2007. Measuring task-related changes in heart rate variability.InProceedings of the Annual Conference of the IEEE Engineering in Medicine and Biology Society.2007: 644\u2013647. doi:10.1109\/IEMBS.2007.4352372. PMID:18002038.","DOI":"10.1109\/IEMBS.2007.4352372"},{"key":"refg54\/ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.02.032"},{"issue":"1","key":"refg55\/ref55","first-page":"10","volume":"58","author":"Musialik-Lydka A.","year":"2003","journal-title":"Kardiol. Pol."},{"key":"refg56\/ref56","doi-asserted-by":"publisher","DOI":"10.1159\/000319564"},{"issue":"3","key":"refg57\/ref57","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1542\/peds.90.3.498","volume":"90","author":"Porges S.W.","year":"1992","journal-title":"Pediatrics"},{"key":"refg58\/ref58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2009.02175.x"},{"key":"refg59\/ref59","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.203166"},{"key":"refg60\/ref60","doi-asserted-by":"publisher","DOI":"10.1016\/0001-4575(94)90051-5"},{"key":"refg61\/ref61","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8760(92)90017-6"},{"key":"refg62\/ref62","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1112"},{"key":"refg63\/ref63","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182009701"},{"key":"refg64\/ref64","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)90670-4"},{"key":"refg65\/ref65","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000100444.71069.73"},{"key":"refg66\/ref66","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000263285.03361.3a"},{"key":"refg67\/ref67","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.51464.x"},{"key":"refg68\/ref68","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-009-9101-z"},{"key":"refg69\/ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.09.543"},{"key":"refg71\/ref71","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.11.2850"},{"key":"refg72\/ref72","unstructured":"Vaa, T. 2003. Impairment, diseases, age and their relative risks of accident involvement: results from meta-analysis, T\u00d8I Report 690 for the Institute of Transport Economics, Oslo, Norway."},{"key":"refg73\/ref73","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8760(96)00058-X"},{"key":"refg74\/ref74","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2006.11.001"},{"key":"refg75\/ref75","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e31816b7303"},{"key":"refg76\/ref76","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-091591"},{"key":"refg77\/ref77","doi-asserted-by":"publisher","DOI":"10.1016\/j.aap.2008.09.006"},{"key":"refg78\/ref78","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1415-9"},{"key":"refg79\/ref79","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.3.290"},{"key":"refg80\/ref80","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2004.07.002"},{"key":"refg81\/ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2010.12.013"}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/full-xml\/10.1139\/cjpp-2012-0342","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/cjpp-2012-0342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T04:30:17Z","timestamp":1644035417000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/cjpp-2012-0342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":79,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1139\/cjpp-2012-0342"],"URL":"https:\/\/doi.org\/10.1139\/cjpp-2012-0342","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}