{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T06:33:24Z","timestamp":1648881204574},"reference-count":37,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>This study tested whether duodenal application of lithium inhibits gastroduodenal motility, and whether it suppresses secretion from the exocrine pancreas. Five suckling pigs, 16\u201318 days old, were surgically fitted with 3 serosal electrodes on the wall of the gastric antrum and the duodenum for electromyography of smooth muscles, and with a pancreatic duct catheter and a duodenal T-cannula for collection and re-entrant flow of pancreatic juice. After the recovery period, on alternative days, each animal was tested once with an intraduodenal infusion of Li+ (100 mmol\u00b7L<jats:sup>\u20131<\/jats:sup>C<jats:sub>3<\/jats:sub>H<jats:sub>5<\/jats:sub>LiO<jats:sub>3,<\/jats:sub>10 mL\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup>) for 1 h, and once with an intraduodenal infusion of NaCl (154 mM, 10 ml\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup>), also for 1 h, with the first treatment, i.e., Li+ or NaCl, randomly assigned. Individual pigs served as their own controls, with data recorded prior to a treatment being used as the baseline. Li+ increased the duration of quiescence (P &lt; 0.05) and activity phase (P &lt; 0.05) in the antrum, thus increasing (P &lt; 0.05) the duration of antral myoelectrical cycles. Li+ shortened (P &lt; 0.05) phase I, but it did not affect phase II or phase III or the MMC in the duodenum. Li+ inhibited pancreatic juice outflow as well as pancreatic enzyme and bicarbonate output (P &lt; 0.05 for all pancreatic parameters).<\/jats:p>","DOI":"10.1139\/cjpp-2012-0396","type":"journal-article","created":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T16:30:24Z","timestamp":1368462624000},"page":"764-772","source":"Crossref","is-referenced-by-count":0,"title":["Duodenal application of Li+ in a submaximal therapeutic dose inhibits exocrine pancreatic secretion and modulates gastro-duodenal myoelectrical activity in a conscious pig model"],"prefix":"10.1139","volume":"91","author":[{"given":"Violetta","family":"Naughton","sequence":"first","affiliation":[{"name":"Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, County Londonderry BT52 1SA, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette S.","family":"Hedemann","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Science and Technology, \u00c5rhus University, Blichers All\u00e9 20, PO Box 50, DK-8830 Tjele, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"Naughton","sequence":"additional","affiliation":[{"name":"Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, County Londonderry BT52 1SA, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emeir","family":"McSorley","sequence":"additional","affiliation":[{"name":"Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, County Londonderry BT52 1SA, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helle N.","family":"Laerke","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Science and Technology, \u00c5rhus University, Blichers All\u00e9 20, PO Box 50, DK-8830 Tjele, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90026-3"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.1997.d01-37.x"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.04241.x"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.1998.00084.x"},{"issue":"3","key":"refg5\/ref5","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0016-5085(94)90689-0","volume":"106","author":"Edelbroek M.","year":"1994","journal-title":"Gastroenterology"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1192\/apt.12.4.256"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6904-11-2"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200202000-00015"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00176.x"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.4077\/CJP.2010.AMH073"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2510160502"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.065946"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.2478\/v10102-010-0011-5"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.4141\/A00-002"},{"issue":"3","key":"refg15\/ref15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1017\/S1357729800055363","volume":"71","author":"Lesniewska V.","year":"2000","journal-title":"Anim. 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