{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:55:44Z","timestamp":1781272544466,"version":"3.54.1"},"reference-count":31,"publisher":"Canadian Science Publishing","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p> Anthracyclines are important anticancer drugs, but their use is limited by cardiotoxicity. Left ventricular ejection fraction (LVEF) is often inadequate to detect myocardial disease induced by chemotherapy. Tissue Doppler and bidimensional-strain imaging could detect LV myocardial dysfunction earlier than LVEF. In drug-induced cardiotoxicity, torsional and longitudinal LV deformations [LV twist (LVtw), radial strain (GRS), global longitudinal strain (GLS)] are damaged. We assessed whether a new index, GLS\u00d7LVtw, could predict future anthracycline-induced cardiomyopathy. Echocardiography, troponin, and natriuretic peptide determination were prospectively performed in 74 patients before and after 6, 12, 24, and 52 weeks of anthracycline treatment. These patients were treated for breast cancer, Hodgkin\u2019s or non-Hodgkin\u2019s lymphoma, acute lymphoblastic or myeloblastic leukaemia, or osteosarcoma. At 6 weeks after initiation of chemotherapy, isovolumic relaxation time, systolic mitral annular velocity, LVGLS, LVGRS, LV apical rotation, LVtw, and GLS\u00d7LVtw deteriorated, and troponin levels became elevated (all p &lt; 0.05 by ANOVA) before LVEF decreased. The receiver operating characteristic curves identified early deterioration of GLS\u00d7LVtw as the best predictor of later cardiotoxicity (area under curve = 0.93), followed by GLS (0.84) and LV apical rotation (0.81) deterioration. In conclusion, early change in the GLS\u00d7LVtw index seems to be a good predictor of future development of anthracycline-induced cardiotoxicity. <\/jats:p>","DOI":"10.1139\/cjpp-2012-0398","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T12:14:54Z","timestamp":1360584894000},"page":"601-607","source":"Crossref","is-referenced-by-count":75,"title":["Early detection of anthracycline-mediated cardiotoxicity: the value of considering both global longitudinal left ventricular strain and twist"],"prefix":"10.1139","volume":"91","author":[{"given":"Cristian","family":"Morno\u015f","sequence":"first","affiliation":[{"name":"\u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Pta. 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