{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T04:19:24Z","timestamp":1746073164582,"version":"3.40.4"},"reference-count":59,"publisher":"Canadian Science Publishing","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>The present study was designed to investigate the effects of YC-1, a nitric oxide (NO)-independent soluble guanylate cyclase (sGC) activator, and DEA\/NO, a NO donor, on smooth muscle responses in the preeclampsia model with suramin-treated rats and on the levels of cyclic guanosine monophosphate (cGMP) of thoracic aorta rings isolated from term-pregnant rats. Rats of 2 groups, control group and suramin group, were given intraperitoneal injection of saline or suramin, respectively. Suramin injection caused increased blood pressure, protein in urine, and fetal growth retardation. Thoracic aorta rings were exposed to contractile and relaxant agents. KCl contraction and papaverine relaxation responses were similar. Relaxation responses of YC-1 and DEA\/NO decreased in suramin group. In both groups in the presence of ODQ, a sGC inhibitor, the relaxation responses of YC-1 and DEA\/NO decreased. The cGMP content was determined by radioimmunoassay technique. The content of cGMP in the suramin group decreased. In the presence of YC-1 and DEA\/NO in both groups, cGMP content increased, but in ODQ-added groups, there was a significant decrease. We conclude that in preeclampsia, the decrease of relaxation responses and the decrease of cGMP content could be due to the reduction in stimulation of sGC and the decrease in cGMP levels.<\/jats:p>","DOI":"10.1139\/cjpp-2013-0086","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T15:13:58Z","timestamp":1369322038000},"page":"797-803","source":"Crossref","is-referenced-by-count":6,"title":["Investigation of the role of the NO\u2013cGMP pathway on YC-1 and DEA\/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model"],"prefix":"10.1139","volume":"91","author":[{"given":"Nergiz Hacer","family":"Turgut","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Cumhuriyet University, Sivas 58140, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tijen Kaya","family":"Temiz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Cumhuriyet University, Sivas 58140, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00fclent","family":"Turgut","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine, Cumhuriyet University, Sivas 58140, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baris","family":"Karadas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Katip \u00c7elebi University, Izmir 35620, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mesut","family":"Parlak","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Cumhuriyet University, Sivas 58140, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ihsan","family":"Bagcivan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Cumhuriyet University, Sivas 58140, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.04.018"},{"issue":"2","key":"refg2\/ref2","first-page":"131","volume":"42","author":"Begum S.","year":"1996","journal-title":"Kobe J. Med. Sci."},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.169375"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026546219962"},{"issue":"6","key":"refg5\/ref5","doi-asserted-by":"crossref","first-page":"C1668","DOI":"10.1152\/ajpcell.1998.275.6.C1668","volume":"275","author":"Bradley K.K.","year":"1998","journal-title":"Am. J. Physiol."},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181b33392"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90500-6"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.4.6.898"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704226"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.94.19"},{"key":"refg59\/ref59","unstructured":"Committee for the Update of the Guide for the Care and Use of Laboratory Animals. 1996. Guide for the care and use of laboratory animals. National Academy Press, NW, Washington, D.C., USA."},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.3109\/10641959509015680"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(87)90034-9"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03599-6"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.05.027"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"issue":"4","key":"refg16\/ref16","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S0026-895X(25)08769-3","volume":"49","author":"Freissmuth M.","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(99)01337-1"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000082524.34487.31"},{"key":"refg19\/ref19","doi-asserted-by":"crossref","first-page":"6863","DOI":"10.1002\/j.1460-2075.1996.tb01078.x","volume":"15","author":"Friebe A.","year":"1996","journal-title":"EMBO J."},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702495"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702099"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-5576(98)00044-6"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(95)02096-B"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005232"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.06.025"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701799"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(90)90439-R"},{"issue":"8","key":"refg28\/ref28","first-page":"454","volume":"31","author":"Li L.","year":"1996","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1177\/1753944708092277"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.110.084426"},{"key":"refg31\/ref31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","volume":"43","author":"Moncada S.","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199304000-00023"},{"issue":"15","key":"refg33\/ref33","first-page":"9661","volume":"266","author":"Nakajima M.","year":"1991","journal-title":"A potent inhibitor of melanoma heparanase and invasion. J. Biol. Chem."},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.07.009"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1159\/000292266"},{"key":"refg36\/ref36","doi-asserted-by":"publisher","DOI":"10.1172\/JCI557"},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009244623717"},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90665-0"},{"key":"refg39\/ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2011.05.026"},{"key":"refg40\/ref40","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-006-0149-8"},{"key":"refg41\/ref41","doi-asserted-by":"publisher","DOI":"10.1024\/0040-5930.63.9.585"},{"key":"refg42\/ref42","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70064-8"},{"key":"refg43\/ref43","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70146-2"},{"key":"refg44\/ref44","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(03)00475-7"},{"key":"refg45\/ref45","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)80044-5"},{"key":"refg46\/ref46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb11528.x"},{"key":"refg47\/ref47","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3976"},{"key":"refg48\/ref48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00163.x"},{"key":"refg49\/ref49","doi-asserted-by":"publisher","DOI":"10.1081\/PRG-200030860"},{"issue":"2","key":"refg50\/ref50","first-page":"565","volume":"32","author":"Tikvica A.","year":"2008","journal-title":"Coll. Antropol."},{"key":"refg51\/ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.04.034"},{"key":"refg52\/ref52","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S8550"},{"key":"refg53\/ref53","doi-asserted-by":"publisher","DOI":"10.1124\/mol.111.075804"},{"key":"refg54\/ref54","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S20181"},{"key":"refg55\/ref55","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-7-79"},{"key":"refg56\/ref56","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)00111-8"},{"key":"refg57\/ref57","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70405-8"},{"key":"refg58\/ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.08.031"}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/full-xml\/10.1139\/cjpp-2013-0086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/cjpp-2013-0086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T11:10:10Z","timestamp":1746011410000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/cjpp-2013-0086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":59,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1139\/cjpp-2013-0086"],"URL":"https:\/\/doi.org\/10.1139\/cjpp-2013-0086","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"type":"print","value":"0008-4212"},{"type":"electronic","value":"1205-7541"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}