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A relationship between angiogenesis and hepatic fibrosis has long been speculated, where the 2 are believed to progress together. In this study, the ability of sildenafil (10 mg\u00b7(kg body mass)<jats:sup>\u20131<\/jats:sup>, orally, once daily) to prevent and also reverse liver fibrosis\/cirrhosis experimentally induced by thioacetamide injection (200 mg\u00b7kg<jats:sup>\u20131<\/jats:sup>, intraperitoneal (i.p.), 3 times\u00b7week<jats:sup>\u20131<\/jats:sup>) in male Sprague\u2013Dawley rats has been investigated. Sildenafil administration, either to prevent or to reverse liver fibrosis\/cirrhosis significantly improved the estimated hepatic functions, reduced hepatic hydroxyproline and, in turn, hepatic collagen content, as well as reducing serum levels of the pro-fibrogenic mediator transforming growth factor \u03b2<jats:sub>1<\/jats:sub>. In co-ordination with such improvement, fibrosis grades declined and fibrosis retracted. Herein, the observed results provide evidence for the potential therapeutic efficacy of sildenafil as an antifibrotic agent. <\/jats:p>","DOI":"10.1139\/cjpp-2013-0181","type":"journal-article","created":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T00:10:13Z","timestamp":1376611813000},"page":"1055-1063","source":"Crossref","is-referenced-by-count":12,"title":["Modulation of thioacetamide-induced liver fibrosis\/cirrhosis by sildenafil treatment"],"prefix":"10.1139","volume":"91","author":[{"given":"Eman","family":"Said","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shehta A.","family":"Said","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nariman M.","family":"Gameil","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsayed M.","family":"Ammar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000025"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2005.00350.x"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1021\/ac60205a053"},{"key":"refg5\/ref5","unstructured":"Bissell, D.M., and Maher, J.J. 1996. 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