{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T09:51:09Z","timestamp":1723024269058},"reference-count":18,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p> We have previously reported that both l-glutamate (l-Glu) and nitric oxide (NO) modulate gastric motility in the nucleus ambiguus (NA). The aim of this study is to explore the potential correlation between the l-Glu and NO. A latex balloon connected to a pressure transducer was inserted into the pylorus through the fundus of anesthetized male Wistar rats to continuously record changes in gastric smooth muscle contractile curves. Pretreatment with the NO-synthase inhibitor N-nitro-l-arginine methylester (l-NAME) did not completely abolish the inhibitory effect of l-Glu on gastric motility, but intravenous injection of the ganglionic blocker hexamethonium bromide (Hb) did. By using a specific N-methyl-d-aspartic acid (NMDA) receptor antagonist, we blocked the inhibitory effect of the NO-donor sodium nitroprusside (SNP) on gastric motility. These results suggest that microinjections of l-Glu into the NA inhibits gastric motility by activating the cholinergic preganglionic neurons, partially through the NMDA receptor \u2013 NO pathway. <\/jats:p>","DOI":"10.1139\/cjpp-2013-0413","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T21:34:46Z","timestamp":1396560886000},"page":"455-459","source":"Crossref","is-referenced-by-count":4,"title":["Microinjection of <scp>l<\/scp>-glutamate into the nucleus ambiguus partially inhibits gastric motility through the NMDA receptor \u2013 nitric oxide pathway"],"prefix":"10.1139","volume":"92","author":[{"given":"Hong-Zhao","family":"Sun","sequence":"first","affiliation":[{"name":"College of Life Science, Qi Lu Normal University, No. 36, Lishan Road, Jinan, Shandong 250013, P.R. 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