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Statin interference with the endogenous synthesis of coenzyme Q<jats:sub>10<\/jats:sub> (CoQ<jats:sub>10<\/jats:sub>) prompted the hypothesis that its deficiency may be implicated in the pathogenesis of statin-associated myopathy. Hence, the effects of combination of CoQ<jats:sub>10<\/jats:sub> with either statin have been evaluated. Rats were rendered hyperlipidemic through feeding them a high-fat diet for 90 days, during the last 30 days of the diet they were treated daily with either atorvastatin, RYR, CoQ<jats:sub>10<\/jats:sub>, or combined regimens. Lipid profile, liver function tests, and creatine kinase were monitored after 15 and 30 days of drug treatments. Heart contents of CoQ<jats:sub>9<\/jats:sub> and CoQ<jats:sub>10<\/jats:sub> were assessed and histopathological examination of the liver and aortic wall was performed. RYR and CoQ<jats:sub>10<\/jats:sub> had the advantage over atorvastatin in that they lower cholesterol without elevating creatine kinase, a hallmark of myopathy. RYR maintained normal levels of heart ubiquinones, which are essential components for energy production in muscles. In conclusion, RYR and CoQ<jats:sub>10<\/jats:sub> may offer alternatives to overcome atorvastatin-associated myopathy. <\/jats:p>","DOI":"10.1139\/cjpp-2013-0430","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T21:38:33Z","timestamp":1398721113000},"page":"481-489","source":"Crossref","is-referenced-by-count":20,"title":["Red yeast rice and coenzyme Q<sub>10<\/sub> as safe alternatives to surmount atorvastatin-induced myopathy in hyperlipidemic rats"],"prefix":"10.1139","volume":"92","author":[{"given":"Marwan","family":"Abdelbaset","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Medical Research Division, National Research Centre, El Tahrir Street, 12622 Giza, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa M.","family":"Safar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawsan S.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Medical Research Division, National Research Centre, El Tahrir Street, 12622 Giza, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seham A.","family":"Negm","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Medical Research Division, National Research Centre, El Tahrir Street, 12622 Giza, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azza M.","family":"Agha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.104.4.539"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0098-2997(94)90028-0"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-12-200906160-00006"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000131519.15067.1f"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.116762"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.12.063"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.04.013"},{"issue":"5","key":"refg8\/ref8","first-page":"413","volume":"56","author":"Coodley E.L.","year":"1971","journal-title":"Am. 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