{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:00:29Z","timestamp":1773766829388,"version":"3.50.1"},"reference-count":60,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>We investigated the potential role of selected excitation\u2013contraction coupling processes in females with work-related myalgia (WRM) by comparing WRM with healthy controls (CON) using tissue from extensor carpi radialis brevis (ECRB) and trapezius (TRAP) muscles. For the ECRB, age (mean \u00b1 SE) was 29.6 \u00b1 3.5 years for CON (n = 9) and 39.2 \u00b1 2.8 years for WRM (n = 13), while for the TRAP, the values were 26.0 \u00b1 2.1 years for CON (n = 7) and 44.6 \u00b1 2.9 years for WRM (n = 11). For the sarcoplasmic reticulum (SR) of the ECRB, WRM displayed concentrations (nmol\u00b7(mg protein)<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>) that were lower (P &lt; 0.05) for Total (202 \u00b1 4.4 vs 178 \u00b1 7.1), Basal (34 \u00b1 1.6 vs 30.1 \u00b1 1.3), and maximal Ca<jats:sup>2+<\/jats:sup>-ATPase activity (V<jats:sub>max<\/jats:sub>, 168 \u00b1 4.9 vs 149 \u00b1 6.3), and Ca<jats:sup>2+<\/jats:sup>-uptake (5.06 \u00b1 0.31 vs 4.13 \u00b1 0.29), but not SERCA1a and SERCA2a isoforms, by comparison with CON. When age was incorporated as a co-variant, Total, Basal, and Ca<jats:sup>2+<\/jats:sup>-uptake remained different from CON (P &lt; 0.05), but not V<jats:sub>max<\/jats:sub>(P = 0.13). For TRAP, none of the ATPase properties differed between groups (P &gt; 0.05) either before or following adjustment for age. No differences (P &gt; 0.05) were observed between the groups for Ca<jats:sup>2+<\/jats:sup>-release in the SR for either TRAP or ECRB. Similarly, no deficiencies, regardless of muscle, were noted for either the Na<jats:sup>+<\/jats:sup>\u2013K<jats:sup>+<\/jats:sup>-ATPase content or the \u03b1 and \u03b2 subunit isoform distribution in WRM. This preliminary study provides a basis for further research, with expanded numbers, investigating the hypothesis that abnormalities in SR Ca<jats:sup>2+<\/jats:sup>-regulation are involved in the cellular etiology of WRM.<\/jats:p>","DOI":"10.1139\/cjpp-2014-0029","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T21:37:14Z","timestamp":1398721034000},"page":"498-506","source":"Crossref","is-referenced-by-count":7,"title":["Excitation\u2013contraction coupling properties in women with work-related myalgia: a preliminary study"],"prefix":"10.1139","volume":"92","author":[{"given":"Howard J.","family":"Green","sequence":"first","affiliation":[{"name":"Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada."},{"name":"Centre of Research Expertise for the Prevention of Musculoskeletal Disorders (CRE-MSD), Faculty of Applied Health Sciences, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don","family":"Ranney","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada."},{"name":"Centre of Research Expertise for the Prevention of Musculoskeletal Disorders (CRE-MSD), Faculty of Applied Health Sciences, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada."},{"name":"Disability Assessment Services, Inc., RR#1 Arthur, Waterloo, ON N0G 1A0, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Burnett","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patti","family":"Galvin","sequence":"additional","affiliation":[{"name":"Wellington Orthopaedic and Rehabilitation Centre, 86 Dawson Road, Unit 3, Guelph, ON N1H 1A8, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Kyle","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lounsbury","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian C.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riley","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Tick","sequence":"additional","affiliation":[{"name":"Mind-Body Medicine, The RSI Clinic, 79 St. Clair Avenue East, Toronto, ON M4T 1M6, Canada."},{"name":"Departments of Family Medicine and Anaesthesiology & Pain Medicine, University of Washington, 1959 NE Pacific Street, BB-1469, Seattle, WA 98195-6540, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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