{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:38:01Z","timestamp":1787017081364,"version":"build-2736575974"},"reference-count":37,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>\n                    Tumor necrosis factor alpha (TNF-\u03b1) plays an important role in the pathogensis of hepatitis C virus (HCV) infection induced liver injury. This study aimed to evaluate the effects of TNF-\u03b1 inhibition with pentoxifylline (PTX) on concanavalin\u2009A (Con\u2009A)-induced hepatic injury in rats. The rats were distributed among 3 groups: (i) control group (1 mL saline\u00b7week\n                    <jats:sup>\u20131<\/jats:sup>\n                    by intravenous injection (i.v.)); (ii) Con\u2009A treatment group (20 mg Con\u2009A\u00b7(kg body mass)\n                    <jats:sup>\u20131<\/jats:sup>\n                    \u00b7week\n                    <jats:sup>\u20131<\/jats:sup>\n                    , i.v.), and (iii) rats treated with Con\u2009A and with PTX (200 mg PTX\u00b7(kg body mass)\n                    <jats:sup>\u20131<\/jats:sup>\n                    \u00b7day\n                    <jats:sup>\u20131<\/jats:sup>\n                    , per oral) group. Blood samples and livers were collected at the end of weeks 1, 2, 4, and 8 of Con\u2009A treatment. Portal pressure (PP) was measured at the end of week 8. The administration of PTX was found to confer significant protection against the injurious effects of Con\u2009A on the liver, by reducing serum levels of aspartate aminotransferase, alanine aminotransferase, hepatic TNF-\u03b1, and malondialdehyde. Histopathological examination revealed that treatment with PTX significantly suppressed early inflammation, reduced alpha smooth muscle actin, and the apoptosis of hepatocytes induced by Con\u2009A. Moreover, PTX significantly (P &lt; 0.05) reduced PP, and quantitative analyses of the area of fibrosis induced by treatment with Con\u2009A showed a significant reduction at the end of week 8. We conclude that rats treated with PTX revealed a more or less normal hepatocyte architecture as well as marked improvement in fibrosis and PP.\n                  <\/jats:p>","DOI":"10.1139\/cjpp-2014-0085","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T19:25:31Z","timestamp":1398281131000},"page":"490-497","source":"Crossref","is-referenced-by-count":10,"title":["Hepatoprotective effects of early pentoxifylline administration on hepatic injury induced by concanavalin A in rat"],"prefix":"10.1139","volume":"92","author":[{"given":"Doaa Ibrahim","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Abdel salam Mohamed","family":"Elmelegy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubna Foaad","family":"A. 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