{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:33:40Z","timestamp":1763116420449,"version":"3.40.4"},"reference-count":46,"publisher":"Canadian Science Publishing","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>This study investigated the role of \u03b1<jats:sub>1D<\/jats:sub>-adrenoceptor in the modulation of renal haemodynamics in rats with left ventricular hypertrophy (LVH). LVH was established in Wistar\u2013Kyoto (WKY) rats with isoprenaline (5.0 mg\u00b7(kg body mass)<jats:sup>\u20131<\/jats:sup>, by subcutaneous injection every 72 h) and caffeine (62 mg\u00b7L<jats:sup>\u20131<\/jats:sup>in drinking water, daily for 14 days). Renal vasoconstrictor responses were measured for noradrenaline (NA), phenylephrine (PE), and methoxamine (ME) before and immediately after low or high dose intrarenal infusions of BMY\u20097378, a selective \u03b1<jats:sub>1D<\/jats:sub>-adrenoceptor blocker. The rats with LVH had higher mean arterial blood pressure and circulating NA levels, but lower renal cortical blood perfusion compared with the control group (all P &lt; 0.05). In the LVH group, the magnitude of the renal vasoconstrictor response to ME was blunted, but not the response to NA or PE (P &lt; 0.05), compared with the control group (LVH vs. C, 38% vs. 50%). The magnitude of the drop in the vasoconstrictor responses to NA, PE, and ME in the presence of a higher dose of BMY\u20097378 was significantly greater in the LVH group compared with the control group (LVH vs. C, 45% vs. 25% for NA, 52% vs. 33% for PE, 66% vs. 53% for ME, all P &lt; 0.05). These findings indicate an impaired renal vasoconstrictor response to adrenergic agonists during LVH. In addition, the \u03b1<jats:sub>1D<\/jats:sub>-adrenoceptor subtype plays a key role in the modulation of vascular responses in this diseased state.<\/jats:p>","DOI":"10.1139\/cjpp-2014-0236","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T09:11:22Z","timestamp":1413969082000},"page":"1029-1035","source":"Crossref","is-referenced-by-count":16,"title":["Functional contribution of \u03b1<sub>1D<\/sub>-adrenoceptors in the renal vasculature of left ventricular hypertrophy induced with isoprenaline and caffeine in Wistar\u2013Kyoto rats"],"prefix":"10.1139","volume":"92","author":[{"given":"Ashfaq","family":"Ahmad","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, University Sains Malaysia, Penang 11800, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munavvar A.","family":"Sattar","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, University Sains Malaysia, Penang 11800, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassaan A.","family":"Rathore","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, University Sains Malaysia, Penang 11800, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad H.","family":"Abdulla","sequence":"additional","affiliation":[{"name":"Department of Physiology, University College Cork, County Cork, Ireland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safia A.","family":"Khan","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, University Sains Malaysia, Penang 11800, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nor A.","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurjeet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Institute for Research in Molecular Medicine (INFORMM), University Sains Malaysia, Minden, Penang, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Johns","sequence":"additional","affiliation":[{"name":"Department of Physiology, University College Cork, County Cork, Ireland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"issue":"1","key":"refg1\/ref1","first-page":"21","volume":"1","author":"Abbas S.A.","year":"2007","journal-title":"Can. 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