{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T20:08:56Z","timestamp":1774469336039,"version":"3.50.1"},"reference-count":41,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p> The effect of acute osteoarthritis (OA) on peripheral nerve fibers (NFs) in synovial tissue, and their association with histological changes were investigated in collagenase-induced OA mice. Collagenase (10 U in 5 \u03bcL saline) was injected into the right knee, and the same volume of saline was injected into the left knee as the control. Mice were sacrificed 1, 2, 3, and 4 weeks after the collagenase injection. Histopathological changes in the knee joints were evaluated. The numbers of protein gene product (PGP) 9.5-, calcitonin-gene-related peptide (CGRP)-, and substance P (SP)-positive NFs in the synovial tissue were determined, and their densities in the tissue were calculated. The densities of PGP 9.5- and CGRP-positive NFs in the synovium were drastically decreased 1 week after the collagenase injection. However, by week 4, the density of PGP 9.5- and CGRP-positive NFs had recovered to 84% and 79% of their normal levels, respectively. Despite the poor correlation between the synovitis score and the density of CGRP- or SP-positive NFs in the synovium, the ossification rate of chondrophytes in chondro\/osteophyte lesions correlated strongly with the density of CGRP-positive NFs (R = 0.855). These results suggest that the ossification of chondrophytes occurred in parallel with the increase in CGRP-positive fiber density in the synovium during the acute phase of collagenase-induced OA. <\/jats:p>","DOI":"10.1139\/cjpp-2014-0446","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T02:13:45Z","timestamp":1425003225000},"page":"435-441","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Changes in peptidergic fiber density in the synovium of mice with collagenase-induced acute arthritis"],"prefix":"10.1139","volume":"93","author":[{"given":"Kohei","family":"Murakami","sequence":"first","affiliation":[{"name":"Laboratory of Toxicology, Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-ourai-kita, Izumisano-shi, Osaka 598-8531, Japan."},{"name":"Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-ourai-kita, Izumisano-shi, Osaka 598-8531, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-ourai-kita, Izumisano-shi, Osaka 598-8531, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saburo","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-ourai-kita, Izumisano-shi, Osaka 598-8531, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380519"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01904415"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2012.03.003"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(90)90171-Z"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90071-R"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650070903"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2004.03.003"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.08.005"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1038\/313054a0"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00270017"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.31.362.602"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(86)90726-X"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90237-V"},{"key":"refg14\/ref14","first-page":"1807","volume":"15","author":"Gr\u00f6nblad M.","year":"1988","journal-title":"J. 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