{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:30:37Z","timestamp":1787319037474,"version":"build-2736575974"},"reference-count":39,"publisher":"Canadian Science Publishing","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Endometritis is one of the main diseases that harms the dairy cow industry. Tanshinone IIA (TIIA), a fat-soluble alkaloid isolated from Salviae miltiorrhizae, has been reported to have potent anti-inflammatory properties. However, the anti-inflammatory effects of TIIA on a mouse model of lipopolysaccharide (LPS)-induced endometritis remain to be elucidated. The purpose of the present study was to investigate the effects of TIIA on LPS-induced mouse endometritis. TIIA was intraperitoneally injected 1 h before and 12 h after perfusion of LPS into the uterus. A histological examination was then performed, and the concentrations of myeloperoxidase (MPO) and nitric oxide (NO) in the uterine tissue were determined. The levels of tumor necrosis factor-\u03b1 (TNF-\u03b1) and interleukin-1\u03b2 (IL-1\u03b2) in a homogenate of the uterus were detected by enzyme-linked immunosorbent assay. The extent of phosphorylation of I\u03baB\u03b1 and p65 was detected by Western blotting. TIIA markedly reduced the infiltration of neutrophils, suppressed MPO activity and the concentration of NO, and attenuated the expression of TNF-\u03b1 and IL-1\u03b2. Furthermore, TIIA inhibited the phosphorylation of the nuclear factor-kappa B (NF-\u03baB) p65 subunit and the degradation of its inhibitor I\u03baB\u03b1. All the results suggest that TIIA has strong anti-inflammatory effects on LPS-induced mouse endometritis.<\/jats:p>","DOI":"10.1139\/cjpp-2015-0003","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T17:46:12Z","timestamp":1430934372000},"page":"967-971","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["TIIA attenuates LPS-induced mouse endometritis by suppressing the NF-\u03baB signaling pathway"],"prefix":"10.1139","volume":"93","author":[{"given":"Xiaopei","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."},{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqiang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."},{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weishi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."},{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."},{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."},{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huatao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."},{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenru","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."},{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongfeng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."},{"name":"Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province 266109, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704103361506"},{"key":"refg2\/ref2","doi-asserted-by":"crossref","first-page":"963","DOI":"10.4049\/jimmunol.163.2.963","volume":"163","author":"Barrios-Rodiles M.","year":"1999","journal-title":"J. Immunol."},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-013-0450-z"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)37006-7"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2014.06.021"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9870-9"},{"key":"refg7\/ref7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/biolreprod\/8.4.491","volume":"8","author":"Champlin A.K.","year":"1973","journal-title":"Biol. Reprod."},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0413-y"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05130.x"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1051\/vetres\/2010025"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2009.01.011"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.09.025"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026004"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.04.031"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2012.09.039"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2007.11.005"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2009.02.001"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000172626.00296.ba"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0045"},{"key":"refg20\/ref20","first-page":"392","volume":"15","author":"Jie S.H.","year":"2007","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2006.05.006"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70318-9"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4288-04.2005"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(03)73832-6"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3047"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2013-6836"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2004.09.002"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-121228"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1100\/2011\/131539"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(07)63020-9"},{"key":"refg31\/ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2010.01.023"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.08.002"},{"key":"refg33\/ref33","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1102567"},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1530\/REP-14-0163"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.02.003"},{"key":"refg36\/ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2013.08.002"},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038381"},{"key":"refg38\/ref38","first-page":"1171","volume":"38","author":"Zhao B.L.","year":"1996","journal-title":"Biochem. Mol. Biol. Int."},{"key":"refg39\/ref39","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9839-8"}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/cjpp-2015-0003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/cjpp-2015-0003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:12:54Z","timestamp":1754482374000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/cjpp-2015-0003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1139\/cjpp-2015-0003"],"URL":"https:\/\/doi.org\/10.1139\/cjpp-2015-0003","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"2015-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}