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Pharmacol."],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p> Given the importance of the aggregation of advanced glycation end products (AGEs) and cardiac inflammation in the onset and progression of diabetic cardiomyopathy (DCM), our objective in this study was to demonstrate the cardioprotective effect of mangiferin, an antidiabetic and anti-inflammatory agent, on diabetic rat model. The DCM model was established by a high-fat diet and a low dose of streptozotocin. DCM rats were treated orally with mangiferin (20 mg\/kg) for 16 weeks. Serum and left ventricular myocardium were collected for determination of inflammatory cytokines. AGEs mRNA and protein expression of nuclear factor kappa B (NF-\u03baB) and receptor for AGEs (RAGE) in myocardium were assayed by real-time PCR and Western blot. ROS levels were measured by dihydroethidium fluorescence staining. NF-\u03baB binding activity was assayed by TransAM NF-\u03baB p65 ELISA kit. Chronic treatment with mangiferin decreased the levels of myocardial enzymes (CK-MB, LDH) and inflammatory mediators (TNF-\u03b1, IL-1\u03b2). Meanwhile, NF-\u03baB is inhibited by the reduction of nuclear translocation of p65 subunit, and mangiferin reduced AGE production and decreased the mRNA and protein expression of RAGE in DCM rats. Our data indicated that mangiferin could significantly ameliorate DCM by preventing the release of inflammatory cytokines, and inhibiting ROS accumulation, AGE\/RAGE production, and NF-\u03baB nuclear translocation, suggesting that mangiferin treatment might be beneficial in DCM. <\/jats:p>","DOI":"10.1139\/cjpp-2015-0073","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T21:37:35Z","timestamp":1446586655000},"page":"332-340","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":81,"title":["Mangiferin suppressed advanced glycation end products (AGEs) through NF-\u03baB deactivation and displayed anti-inflammatory effects in streptozotocin and high fat diet-diabetic cardiomyopathy rats"],"prefix":"10.1139","volume":"94","author":[{"given":"Jun","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Chengdu Military General Hospital, Chengdu, China."},{"name":"Centre for Heart Lung Innovation, St. Paul\u2019s Hospital, Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Jinan Military General Hospital, Jinan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Fung","sequence":"additional","affiliation":[{"name":"Centre for Heart Lung Innovation, St. Paul\u2019s Hospital, Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Deng","sequence":"additional","affiliation":[{"name":"Centre for Heart Lung Innovation, St. Paul\u2019s Hospital, Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Jinan Military General Hospital, Jinan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chengdu Military General Hospital, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghe","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Chengdu Military General Hospital, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/936486"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.05.001"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.050500"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.7.1813"},{"key":"refg54\/ref54","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.58"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223545"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.09.003"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000342128"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2013-0090"},{"key":"refg51\/ref51","unstructured":"ILAR (Institute of Laboratory Animal Resources). 2010. 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