{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:08:55Z","timestamp":1751515735620,"version":"3.41.0"},"reference-count":32,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p> Ascending and descending neuromuscular reflexes play an important role in gastrointestinal motility. However, the underlying mechanisms in colon are incompletely understood. Nerve stimulation (NS)- and balloon distention (BD)-mediated reflexes in distal colonic circular smooth muscle (CSM) and longitudinal smooth muscle (LSM) of mice were investigated using conventional intracellular recordings. In the CSM, NS evoked ascending purinergic inhibitory junction potentials (IJPs), whereas BD induced atropine-sensitive ascending depolarization with superimposed action potentials (APs). The ascending depolarization reached a peak \u223c4\u20137 s after the onset of distention and gradually returned to baseline after termination of the distention. In the LSM, NS produced an ascending biphasic IJP followed by a train of atropine-sensitive APs. Both stimuli produced similar descending IJPs in CSM and LSM, which were blocked by MRS-2500 and MRS-2179, putative purinergic receptor blockers. These data indicate that in the murine distal colon, descending purinergic inhibition in both CSM and LSM occurs. Ascending responses are more complex, with NS producing both inhibition and excitation to CSM and LSM, and BD evoking only cholinergic excitation. <\/jats:p>","DOI":"10.1139\/cjpp-2015-0086","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T21:38:29Z","timestamp":1438897109000},"page":"190-198","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Characterization of the peristaltic reflex in murine distal colon"],"prefix":"10.1139","volume":"94","author":[{"given":"Yong","family":"Zhang","sequence":"first","affiliation":[{"name":"Gastrointestinal Diseases Research Unit, Queen\u2019s University and Kingston General Hospital, Kingston, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Paterson","sequence":"additional","affiliation":[{"name":"Gastrointestinal Diseases Research Unit and the Departments of Biology, Biomedical and Molecular Sciences, and Medicine, Queen\u2019s University and Kingston General Hospital, Kingston, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.196824"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1899.sp000752"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1900.sp000825"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(94)00149-E"},{"key":"refg5\/ref5","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0022-3565(25)22561-7","volume":"270","author":"Ciccocioppo R.","year":"1994","journal-title":"J. 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