{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:13:46Z","timestamp":1791893626348,"version":"4.3.4"},"reference-count":60,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p> Insulin resistance increases risk of cardiovascular diseases. This work investigated the protective effect of pioglitazone on myocardial infarction (MI) in non-diabetic and diabetic rats, focusing on its role on advanced glycated endproducts (AGEs) and cardiac apoptotic machinery. Male rats were divided into 2 experiments: experiment I and II (non-diabetic and diabetic rats) were assigned as saline, MI (isoproterenol, 85 mg\/kg, daily), and MI+pioglitazone (5, 10, and 20 mg\/kg). Injection of isoproterenol in diabetic rats produced greater ECG disturbances compared to non-diabetic rats. Treatment with pioglitazone (5 mg\/kg) reduced the infarct size and improved some ECG findings. Pioglitazone (10 mg\/kg) enhanced ECG findings, improved the histopathological picture and downregulated apoptosis in cardiac tissues. Whereas the higher dose of pioglitazone (20 mg\/kg) did not improve most of the measured parameters but rather worsened some of them, such as proapoptotic markers. Importantly, a positive correlation was found between serum AGEs and cardiac AGE receptors (RAGEs) versus caspase 3 expression in the two experiments. Therefore, the current effect of pioglitazone was, at least in part, mediated through downregulation of AGE-RAGE axis and inhibition of apoptosis. Consequently, these data suggest that pioglitazone, at optimized doses, may have utility in protection from acute MI. <\/jats:p>","DOI":"10.1139\/cjpp-2015-0135","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T21:36:42Z","timestamp":1438205802000},"page":"463-476","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Cardioprotective effect of pioglitazone in diabetic and non-diabetic rats subjected to acute myocardial infarction involves suppression of AGE-RAGE axis and inhibition of apoptosis"],"prefix":"10.1139","volume":"94","author":[{"given":"Dina M.","family":"Khodeer","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, 41522 Ismailia, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawsan A.","family":"Zaitone","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, 41522 Ismailia, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha E.","family":"Farag","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser M.","family":"Moustafa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, 41522 Ismailia, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2003.10.054"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2014-0524"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.09.011"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2003.10.011"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.m600235-jlr200"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-10-0402"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.7.1135"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000039325.03698.36"},{"key":"refg9\/ref9","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/clinchem\/24.5.828","volume":"24","author":"Buhl S.N.","year":"1978","journal-title":"Clin. 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