{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:30:26Z","timestamp":1790717426496,"version":"4.1.0"},"reference-count":41,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>The role of hyperhomocysteinemia in coronary artery disease (CAD) patients remains unclear. The present study evaluated the relationship between homocysteine (HCys), adenosine plasma concentration (APC), plasma uric acid, and CAD severity evaluated using the SYNTAX score. We also evaluated in vitro the influence of adenosine on HCys production by hepatoma cultured cells (HuH7). Seventy-eight patients (mean age \u00b1 SD: 66.3 \u00b1 11.3; mean SYNTAX score: 19.9 \u00b1 12.3) and 30 healthy subjects (mean age: 61 \u00b1 13) were included. We incubated HuH7 cells with increasing concentrations of adenosine and addressed the effect on HCys level in cell culture supernatant. Patients vs. controls had higher APC (0.82 \u00b1 0.5 \u03bcmol\/L vs 0.53 \u00b1 0.14 \u03bcmol\/L; p &lt; 0.01), HCys (15 \u00b1 7.6 \u03bcmol\/L vs 6.8 \u00b1 3 \u03bcmol\/L, p &lt; 0.0001), and uric acid (242.6 \u00b1 97 vs 202 \u00b1 59, p &lt; 0.05) levels. APC was correlated with HCys and uric acid concentrations in patients (Pearson\u2018s R = 0.65 and 0.52; p &lt; 0.0001, respectively). The SYNTAX score was correlated with HCys concentration. Adenosine induced a time- and dose-dependent increase in HCys in cell culture. Our data suggest that high APC is associated with HCys and uric acid concentrations in CAD patients. Whether the increased APC participates in atherosclerosis or, conversely, is part of a protective regulation process needs further investigations.<\/jats:p>","DOI":"10.1139\/cjpp-2015-0193","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T17:36:14Z","timestamp":1440783374000},"page":"272-277","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Adenosine plasma level correlates with homocysteine and uric acid concentrations in patients with coronary artery disease"],"prefix":"10.1139","volume":"94","author":[{"given":"J.","family":"Fromonot","sequence":"first","affiliation":[{"name":"UMR MD2, Aix Marseille University and IRBA (Institute of Research in Biology of the French Army), School of Medicine, Bvd P Dramard 13015 Marseille, France."},{"name":"Laboratory of Biochemistry, Timone University Hospital, Marseille, 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