{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:12:45Z","timestamp":1790885565933,"version":"4.1.0"},"reference-count":56,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p> Melatonin is known for being beneficial in targeting liver diseases. This study aimed to investigate whether melatonin post-treatment is capable of rat carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)-induced liver fibrosis reduction. Thirty-two male Sprague-Dawley rats were divided into 4 groups: normal; fibrosis with CCl<jats:sub>4<\/jats:sub> injection (1 mL\/kg) twice weekly for 8 weeks; phosphate-buffered saline (PBS); and melatonin (20 mg\/kg) for a further 4 weeks on cessation of CCl<jats:sub>4<\/jats:sub>. At the beginning of week 13, liver tissue samples were used for hematoxylin-eosin (H&amp;E), periodic acid-Schiff (PAS), Masson\u2019s trichrome (MT), and Oil Red O staining, quantitative real-time PCR (qRT-PCR) analysis of the matrix metalloproteinase-9 (MMP-9), MMP-13, transforming growth factor-\u03b21 (TGF-\u03b21), Bcl-2, and Bax genes as well as immunofluorescence (IF) of the first 3, and sera for measurement of aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, and hydroxyproline. Chronic administration of CCl<jats:sub>4<\/jats:sub> followed by considerable increase in tissue disruption, macro- and micro-vesicles, collagen, lipid droplets (LDs), AST, ALT, hydroxyproline, TGF-\u03b21, and Bax, and decrease in glycogen depository, albumin, Bcl-2, MMP-9, and MMP-13; however, the pattern was reverse when it comes to melatonin treatment (for all p &lt; 0.05). Our results reveal the beneficial aspects of melatonin in treatment of liver fibrosis probably via inhibition of TGF-\u03b21expression. <\/jats:p>","DOI":"10.1139\/cjpp-2015-0266","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T21:37:21Z","timestamp":1437428241000},"page":"119-130","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Therapeutic value of melatonin post-treatment on CCl<sub>4<\/sub>-induced fibrotic rat liver"],"prefix":"10.1139","volume":"94","author":[{"given":"Keywan","family":"Mortezaee","sequence":"first","affiliation":[{"name":"Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Poursina Street, Tehran, Iran, 1417613151."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Sabbaghziarani","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Poursina Street, Tehran, Iran, 1417613151."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameneh","family":"Omidi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Poursina Street, Tehran, Iran, 1417613151."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Reza","family":"Dehpour","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Omidi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ziaian Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soudabeh","family":"Ghasemi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Poursina Street, Tehran, Iran, 1417613151."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parichehr","family":"Pasbakhsh","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Poursina Street, Tehran, Iran, 1417613151."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iraj","family":"Ragerdi Kashani","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Poursina Street, Tehran, Iran, 1417613151."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.3797\/scipharm.1006-02"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17552"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2003.11.020"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1002\/jat.758"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0941"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1525-6"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2014.10.003"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2005.01169.x"},{"issue":"393","key":"refg9\/ref9","first-page":"49","volume":"100","author":"Drobnik J.","year":"1998","journal-title":"Cytobios"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.04.023"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0533-7"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310117"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i24.3781"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1177\/019262339902700512"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.3727\/096368909788237140"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.13"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21477"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1452"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/480714"},{"issue":"1","key":"refg20\/ref20","first-page":"44","volume":"53","author":"Jaswal A.","year":"2015","journal-title":"Indian J. 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