{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:12:38Z","timestamp":1777468358045,"version":"3.51.4"},"reference-count":34,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p> The effects of chronic treatment with digitoxin on arterial baroreceptor sensitivity for heart rate (HR) and renal sympathetic nerve activity (rSNA) control, cardiopulmonary reflex, and autonomic HR control in an animal model of heart failure (HF) were evaluated. Wistar rats were treated with digitoxin, which was administered in their daily feed (1 mg\/kg per day) for 60 days. The following 3 experimental groups were evaluated: sham, HF, and HF treated with digitoxin (HF + DIG). We observed an increase in rSNA in the HF group (190 \u00b1 29 pps, n = 5) compared with the sham group (98 \u00b1 14 pps, n = 5). Digitoxin treatment prevented an increase in rSNA (98 \u00b1 14 pps, n = 7). Therefore, arterial baroreceptor sensitivity was decreased in the HF group (\u22121.24 \u00b1 0.07 bpm\/mm Hg, n = 8) compared with the sham group (\u22122.27 \u00b1 0.23 bpm\/mm Hg, n = 6). Digitoxin did not alter arterial baroreceptor sensitivity in the HF + DIG group. Finally, the HF group showed an increased low frequency band (LFb: 23 \u00b1 5 ms<jats:sup>2<\/jats:sup>, n = 8) and a decreased high frequency band (HFb: 77 \u00b1 5 ms<jats:sup>2<\/jats:sup>, n = 8) compared with the sham group (LFb: 14 \u00b1 3 ms<jats:sup>2<\/jats:sup>; HFb: 86 \u00b1 3 ms<jats:sup>2<\/jats:sup>, n = 9); the HF+DIG group exhibited normalized parameters (LFb: 15 \u00b1 3 ms<jats:sup>2<\/jats:sup>; HFb: 85 \u00b1 3 ms<jats:sup>2<\/jats:sup>, n = 9). In conclusion, the benefits of decreasing rSNA are not directly related to improvements in peripheral cardiovascular reflexes; such occurrences are due in part to changes in the central nuclei of the brain responsible for autonomic cardiovascular control. <\/jats:p>","DOI":"10.1139\/cjpp-2015-0354","type":"journal-article","created":{"date-parts":[[2016,1,17]],"date-time":"2016-01-17T22:36:13Z","timestamp":1453070173000},"page":"643-650","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Digitoxin improves cardiovascular autonomic control in rats with heart failure"],"prefix":"10.1139","volume":"94","author":[{"given":"N\u00fabia Mantovan","family":"Fardin","sequence":"first","affiliation":[{"name":"Cardiovascular Division, Department of Physiology, Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Rua Botucatu, 862, CEP 04023-060, S\u00e3o Paulo, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ednei Luiz","family":"Antonio","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jairo Augusto Silva","family":"Montemor","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glaucia Luciano","family":"da Veiga","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Physiology, Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Rua Botucatu, 862, CEP 04023-060, S\u00e3o Paulo, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Jos\u00e9 Ferreira","family":"Tucci","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruy R.","family":"Campos","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Physiology, Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Rua Botucatu, 862, CEP 04023-060, S\u00e3o Paulo, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.01.007"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.03.440"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2012.10.005"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp100202"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.01.030"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.65.6.1526"},{"issue":"5","key":"refg7\/ref7","first-page":"R1189","volume":"269","author":"DiBona G.F.","year":"1995","journal-title":"Am. 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