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Etiologies for SCD include cardiac arrhythmias, coronary artery disease, congenital coronary artery anomalies, hypertrophic cardiomyopathy, arrhythmogenic right ventricular dysplasia, dilated cardiomyopathy, and aortic valve stenosis. A potential unifying mechanism of SCD in these diseases involves a massive stimulation of the sympathetic nervous system\u2019s stress response and the subsequent elevation of circulating catecholamines. The diagnosis of cardiac diseases that contribute to an increased risk for SCD is accomplished by a combination of different techniques including electrocardiography, echocardiography, magnetic resonance imaging, and invasive cardiac catheterization. Several therapies including anti-arrhythmic drugs, \u03b2-blockers, and antiplatelet agents may be used as medical treatment in patients for the prevention of SCD. Invasive therapies including percutaneous angioplasty, coronary artery bypass surgery, and implantable cardioverter-defibrillators are also used in the clinical management of SCD. <\/jats:p>","DOI":"10.1139\/cjpp-2015-0366","type":"journal-article","created":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T21:35:56Z","timestamp":1442525756000},"page":"237-244","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Pathophysiology and prevention of sudden cardiac death"],"prefix":"10.1139","volume":"94","author":[{"given":"Vineet","family":"Goyal","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, 351 Tache Avenue, Department of Physiology and Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R2H 2A6, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davinder S.","family":"Jassal","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, 351 Tache Avenue, Department of Physiology and Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R2H 2A6, Canada."},{"name":"Section of Cardiology, Department of Internal Medicine, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naranjan S.","family":"Dhalla","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, 351 Tache Avenue, Department of Physiology and Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R2H 2A6, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.11.009"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1139\/Y09-042"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.11.011"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90416-0"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.22.2727"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2013.06.016"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1182"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.5.983"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi341"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1002\/jat.793"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2009.02378.x"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0346"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2014.10.012"},{"issue":"2","key":"refg15\/ref15","first-page":"18","volume":"53","author":"Bouska I.","year":"2008","journal-title":"Soud. 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