{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T01:09:42Z","timestamp":1775005782917,"version":"3.50.1"},"reference-count":30,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p> A further investigation was performed on the vascular effect of endogenous histamine using the histamine releaser, compound 48\/80, in rat mesenteric vascular beds with active tone. In preparations with intact endothelium, low concentrations of compound 48\/80 (1.53 \u00d7 10<jats:sup>\u22125<\/jats:sup> \u2013 3 \u00d7 1.53 \u00d7 10<jats:sup>\u22125<\/jats:sup> mg\/mL) perfusion for 1 min only induced a small vasodilation. High concentrations of compound 48\/80 (1.53 \u00d7 10<jats:sup>\u22124<\/jats:sup> \u2013 3 \u00d7 1.53 \u00d7 10<jats:sup>\u22122<\/jats:sup> mg\/mL) induced a biphasic vascular responses, an initial vasoconstriction followed a subsequent long-lasting vasodilation. The vasodilation induced by low concentrations of compound 48\/80 and the vasoconstriction induced by high concentration of compound 48\/80 was inhibited by olopatadine. However, cimetidine did not affect the responses induced by compound 48\/80. Endothelium removal enlarged the compound 48\/80-induced phase-2 vasoconstriction, while it attenuated the phase-3 vasodilation. Additionally, indomethacin and seratrodast significantly inhibited vasoconstriction but it did not affect the long-lasting vasodilation induced by high concentrations of compound 48\/80. Ruthenium red inhibited the vasodilation induced by low concentrations and high concentrations of compound 48\/80. These results suggest that the vasoconstriction induce by high concentrations of compound 48\/80 is mediated by endogenous histamine released from mast cells. It is also suggested that thromboxane A<jats:sub>2<\/jats:sub> released from mast cells is related to the vasoconstriction. <\/jats:p>","DOI":"10.1139\/cjpp-2015-0442","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T22:38:07Z","timestamp":1452897487000},"page":"620-626","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Vascular responses to compound 48\/80 in rat mesenteric vascular beds"],"prefix":"10.1139","volume":"94","author":[{"given":"Honghua","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Affiliated Hospital of Yanbian University, Yanji 133000, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Takatori","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan."},{"name":"Department of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University, Matsuyama, Ehime 790-8578, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Zamami","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromu","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan."},{"name":"Department of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University, Matsuyama, Ehime 790-8578, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.17.732"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702838"},{"issue":"6","key":"refg3\/ref3","first-page":"582","volume":"23","author":"Buzato M.A.","year":"2005","journal-title":"Shock, (Augusta, Ga.)"},{"issue":"1","key":"refg30\/ref30","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0022-3565(24)35267-X","volume":"292","author":"Chahdi A.","year":"2000","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01480-5"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1980.tb07940.x"},{"issue":"2","key":"refg6\/ref6","first-page":"264","volume":"267","author":"Friedrich G.","year":"1984","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1006\/bmme.1997.2594"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1007\/BF01969005"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.12012SC"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.11.6155"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.10.060"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.01.018"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1038\/335164a0"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.126811"},{"issue":"7542","key":"refg15\/ref15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature14022","volume":"519","author":"McNeil B.D.","year":"2015","journal-title":"Nature"},{"issue":"4","key":"refg16\/ref16","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1152\/physrev.1997.77.4.1033","volume":"77","author":"Metcalfe D.D.","year":"1997","journal-title":"Physiol. Rev."},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1951.tb00661.x"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12417"},{"key":"refg19\/ref19","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/BF02024193","volume":"10","author":"Pearce F.L.","year":"1980","journal-title":"Agents actions."},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70313-5"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.27.1270"},{"issue":"10","key":"refg22\/ref22","first-page":"5136","volume":"160","author":"Senyshyn J.","year":"1998","journal-title":"J. Immunol. (Baltimore, Md.)"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(02)00025-4"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.33.58"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.01.020"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(61)90062-3"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00641.x"},{"issue":"16","key":"refg28\/ref28","doi-asserted-by":"crossref","first-page":"5673","DOI":"10.1016\/S0021-9258(19)43558-8","volume":"248","author":"Wlodawer P.","year":"1973","journal-title":"J. Biol. Chem."},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270143"}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/cjpp-2015-0442","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/cjpp-2015-0442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T17:42:59Z","timestamp":1751478179000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/cjpp-2015-0442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1139\/cjpp-2015-0442"],"URL":"https:\/\/doi.org\/10.1139\/cjpp-2015-0442","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"2015-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}