{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:05:32Z","timestamp":1792652732147,"version":"4.5.0"},"reference-count":45,"publisher":"Canadian Science Publishing","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p> The objectives of present study were to examine the effects of aluminum oxide (Al<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>) nanoparticles on myocardial functions, electrical activities, morphology, inflammation, redox state, and myocardial expression of connexin 43 (Cx43) and the effect of gallic acid (GA) on these effects in a rat animal model. Forty male albino rats were divided into 4 equal groups: the control (normal) group; the Al<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> group, rats received Al<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> (30 mg\u00b7kg<jats:sup>\u20131<\/jats:sup>, i.p.) daily for 14 days; the nano-alumina group, rats received nano-alumina (30 mg\u00b7kg<jats:sup>\u20131<\/jats:sup>, i.p.) daily for 14 days; and the nano-alumina + GA group, rats received GA (100 mg\u00b7kg<jats:sup>\u20131<\/jats:sup> orally once daily) for 14 days before nano-alumina administration. The results showed disturbed ECG variables and significant increases in serum levels of LDH, creatine phosphokinase (CPK), CK-MB, triglycerides (TGs), cholesterol and LDL, nitric oxide (NO), and TNF-\u03b1 and myocardial concentrations of NO, TNF-\u03b1, and malondialdehyde (MDA), with significant decreases in serum HDL and myocardial GSH, SOD, catalase (CAT), and Cx43 expression in the nano-alumina group. Pretreatment with GA improved significantly all parameters except serum and myocardial NO. We concluded that chronic administration of Al<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> NPs caused myocardial dysfunctions, and pretreatment with GA ameliorates myocardial injury induced by nano-alumina, probably through its hypolipidaemic, anti-inflammatory, and antioxidant effects and upregulation of Cx43 in heart. <\/jats:p>","DOI":"10.1139\/cjpp-2015-0446","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T22:40:15Z","timestamp":1457217615000},"page":"868-878","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":59,"title":["Effects of aluminum oxide (Al<sub>2<\/sub>O<sub>3<\/sub>) nanoparticles on ECG, myocardial inflammatory cytokines, redox state, and connexin 43 and lipid profile in rats: possible cardioprotective effect of gallic acid"],"prefix":"10.1139","volume":"94","author":[{"given":"El-Hussainy M.A.","family":"El-Hussainy","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Kafrelsheikh University, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelaziz M.","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Mansoura University, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza","family":"Abdel-Aziz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Mansoura University, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"El-Mehasseb","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Science, Kafrelsheikh University, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2007.04.002"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/gep003"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-008-9131-5"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-6-80"},{"key":"refg5\/ref5","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1093\/clinchem\/36.8.1440","volume":"36","author":"Cortas N.K.","year":"1990","journal-title":"Clin. 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