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The present study was designed to investigate whether administration of Gent would alleviate the expression of nociceptive behaviors and whether it would cause the relevant electrophysiological changes in a chronic constriction injury (CCI) model of neuropathic pain in mice. Gent was administered from the seventh day after surgery for 8 consecutive days. Behavioral parameters and sciatic functional index were assessed immediately before surgery and on days 7, 8, 10, 12, and 14 post-CCI, and electrophysiological activities of sciatic nerve were recorded immediately after the behavioral test on the last day. The present study has shown that administration of Gent (at a dose of 50 and 100 mg\/kg) increased behavioral parameters from day 8 compared with the CCI-NS group. Electrophysiological data indicated that CCI caused a significant reduction in nerve conduction velocities in the sciatic nerves and the amplitudes of compound action potential, while Gent at a dose of 50 or 100 mg\/kg caused a significant recovery of electrophysiological changes induced by CCI. Our data indicated that Gent has antinociceptive effects on neuropathic pain induced by CCI. <\/jats:p>","DOI":"10.1139\/cjpp-2015-0462","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T02:42:22Z","timestamp":1457145742000},"page":"769-778","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Antinociceptive effects of gentiopicroside on neuropathic pain induced by chronic constriction injury in mice: a behavioral and electrophysiological study"],"prefix":"10.1139","volume":"94","author":[{"given":"Ning","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Ningxia Medical University, Yinchuan 750000, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Nursing, Ningxia Medical University, Yinchuan 750004, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai-Shuai","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ningxia Medical University, Yinchuan 750000, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ningxia Medical University, Yinchuan 750000, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ningxia Medical University, Yinchuan 750000, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-Ju","family":"Jin","sequence":"additional","affiliation":[{"name":"Luohe Medical College, Luohe 462002, Henan Province, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Jun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan 750000, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Niu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan 750004, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Sun","sequence":"additional","affiliation":[{"name":"Ningxia Key Lab of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Ningxia Medical University, Yinchuan 750004, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Qiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ningxia Medical University, Yinchuan 750000, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.09.030"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.03.007"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.10.012"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(200006)218:2%3C213::AID-DVDY1%3E3.0.CO;2-R"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00304-8"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2012.704956"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)90145-7"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(82)90234-5"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00276-1"},{"issue":"12","key":"refg101\/ref101","first-page":"106","volume":"5","author":"Dong M.","year":"2014","journal-title":"Chinese Journal of Practical Nervous Disease"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1002\/jps.3030460322"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000055433.55136.55"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00349-9"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00253-7"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12516"},{"key":"refg17\/ref17","first-page":"1","volume":"79","author":"Gutmann E.","year":"1945","journal-title":"J. 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