{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T01:27:58Z","timestamp":1775870878367,"version":"3.50.1"},"reference-count":20,"publisher":"Canadian Science Publishing","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p> Clinical studies have shown that large doses of prednisone could lower serum uric acid (SUA) in patients with decompensated heart failure (HF); however, the optimal dose of prednisone and underlying mechanisms are unknown. Thirty-eight patients with decompensated HF were randomized to receive standard HF care alone (n = 10) or with low-dose (15 mg\/day, n = 8), medium-dose (30 mg\/day, n = 10), or high-dose prednisone (60 mg\/day, n = 10), for 10 days. At the end of the study, only high-dose prednisone significantly reduced SUA, whereas low- and medium-dose prednisone and standard HF care had no effect on SUA. The reduction in SUA in high-dose prednisone groups was associated with a significant increase in renal uric acid clearance. In conclusion, prednisone can reduce SUA levels by increasing renal uric acid clearance in patients with decompensated HF. <\/jats:p>","DOI":"10.1139\/cjpp-2015-0490","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T22:40:23Z","timestamp":1450392023000},"page":"797-800","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Prednisone lowers serum uric acid levels in patients with decompensated heart failure by increasing renal uric acid clearance"],"prefix":"10.1139","volume":"94","author":[{"given":"Chao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Hebei Medical University, Shijiazhuang, China."},{"name":"Heart Center, The First Hospital of Hebei Medical University, 89 Donggang Road, Shijiazhuang, Hebei Province 050031, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhi","family":"Zhen","sequence":"additional","affiliation":[{"name":"Heart Center, The First Hospital of Hebei Medical University, 89 Donggang Road, Shijiazhuang, Hebei Province 050031, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingzhen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Heart Center, The First Hospital of Hebei Medical University, 89 Donggang Road, Shijiazhuang, Hebei Province 050031, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Long","family":"Zhai","sequence":"additional","affiliation":[{"name":"Heart Center, The First Hospital of Hebei Medical University, 89 Donggang Road, Shijiazhuang, Hebei Province 050031, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunshen","family":"Liu","sequence":"additional","affiliation":[{"name":"Heart Center, The First Hospital of Hebei Medical University, 89 Donggang Road, Shijiazhuang, Hebei Province 050031, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Hebei Medical University, Shijiazhuang, China."},{"name":"361 East Zhongshan Road, Department of Pharmacology, Hebei Medical University, Shijiazhuang, Hebei 050017, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.78.1.39"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000065637.10517.A0"},{"issue":"6","key":"refg3\/ref3","doi-asserted-by":"crossref","first-page":"R1972","DOI":"10.1152\/ajpcell.1997.273.6.C1972","volume":"273","author":"De Matteo R.","year":"1997","journal-title":"Am. 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