{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:27:17Z","timestamp":1770834437093,"version":"3.50.1"},"reference-count":24,"publisher":"Canadian Science Publishing","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p> Monoamine oxidases (MAOs) are mitochondrial enzymes with 2 isoforms that have emerged as important contributors to cardiovascular oxidative stress via the constant generation of hydrogen peroxide. The present study was purported to assess whether MAO-derived H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> contributes to the endothelial dysfunction in mammary arteries harvested from coronary heart disease patients with and without diabetes mellitus subjected to coronary artery bypass grafting. To this aim, the effects of MAO inhibition on vascular contractility to phenylephrine and endothelial-dependent relaxation (EDR) in response to acetylcholine were studied in vascular segments. Clorgyline (irreversible MAO-A inhibitor), selegiline (irreversible MAO-B inhibitor), and moclobemide (reversible MAO-A inhibitor) were applied in the organ bath (10 \u03bcmol\/L). MAO expression was assessed by immunohistochemistry. We found a constant impairment of EDR that has been significantly attenuated in the presence of the MAO-A and MAO-B inhibitors in both groups of coronary heart disease patients. MAO-B was the dominant isoform in all human diseased vessels. In conclusion, in vitro inhibition of MAO significantly improved EDR in human mammary arteries, regardless of the presence of diabetes. These data suggest that MAO inhibitors might be useful in restoring endothelial response in clinical conditions associated with increased oxidative stress, such as coronary artery disease and diabetes. <\/jats:p>","DOI":"10.1139\/cjpp-2015-0580","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T21:34:13Z","timestamp":1458682453000},"page":"1040-1047","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["Monoamine oxidase inhibition improves vascular function in mammary arteries from nondiabetic and diabetic patients with coronary heart disease"],"prefix":"10.1139","volume":"94","author":[{"given":"Rodica","family":"Lighezan","sequence":"first","affiliation":[{"name":"Department of Parasitology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Timi\u015foara, Romania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Sturza","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 2, Eftimie Murgu Sq., 300041 Timi\u015foara, Romania."},{"name":"Center for Translational Research and Systems Medicine, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Timi\u015foara, Romania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oana M.","family":"Duicu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 2, Eftimie Murgu Sq., 300041 Timi\u015foara, Romania."},{"name":"Center for Translational Research and Systems Medicine, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Timi\u015foara, Romania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raluca A.","family":"Ceausu","sequence":"additional","affiliation":[{"name":"Department of Histology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Timi\u015foara, Romania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Vaduva","sequence":"additional","affiliation":[{"name":"Department of Morphopathology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Timi\u015foara, Romania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Gaspar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Timi\u015foara, Romania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horea","family":"Feier","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Timi\u015foara, Romania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Vaida","sequence":"additional","affiliation":[{"name":"Department of Anatomy, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Timi\u015foara, Romania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Ivan","sequence":"additional","affiliation":[{"name":"Department of Cardiology - 2nd Cardiology Clinic, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Timi\u015foara, Romania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lighezan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Timi\u015foara, Romania."},{"name":"Center for Translational Research and Systems Medicine, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Timi\u015foara, Romania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danina M.","family":"Muntean","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 2, Eftimie Murgu Sq., 300041 Timi\u015foara, Romania."},{"name":"Center for Translational Research and Systems Medicine, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Timi\u015foara, Romania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Mornos","sequence":"additional","affiliation":[{"name":"Department of Cardiology - 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