{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:03:37Z","timestamp":1760425417772,"version":"3.41.0"},"reference-count":47,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p> Edaravone, a radical scavenger, has been recognized as a potential protective agent for cardiovascular diseases. However, little is known about the effect of edaravone in cardiac complications associated with diabetes. Here, we have demonstrated that edaravone prevents cardiac dysfunction and apoptosis in the streptozotocin-induced type 1 diabetic rat heart. Mechanistic studies revealed that edaravone treatment improved cardiac function and restored superoxide dismutase levels. In addition, treatment of diabetic animals by edaravone increased protein expressions of sirtuin-1 (SIRT-1), peroxisome proliferator activated receptor \u03b3 coactivator \u03b1 (PGC-1\u03b1), nuclear factor like-2 (NRF-2), and B cell lymphoma 2 (Bcl-2), and reduced protein expressions of Bax and Caspase-3 compared to the control group. High glucose incubation resulted in the production of reactive oxygen species (ROS) and cell death. Treatment of high-glucose-incubated H9c2 cells by edaravone reduced ROS production and cell death. In addition, the treatment of high-glucose-incubated H9c2 cells by edaravone increased the activity of antioxidative stress by increasing SIRT-1, PGC-1\u03b1, and NRF-2, and this treatment also reduced apoptosis by increasing Bcl-2 expression and reducing Bax and Caspase-3 expressions. Knockdown SIRT-1 with small interferer RNA abolished the effects of edaravone. Overall, our data demonstrated that edaravone may be an effective agent against the development of diabetic cardiomyopathy. <\/jats:p>","DOI":"10.1139\/cjpp-2015-0587","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T21:35:25Z","timestamp":1463607325000},"page":"996-1006","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["The antioxidant edaravone prevents cardiac dysfunction by suppressing oxidative stress in type 1 diabetic rats and in high-glucose-induced injured H9c2 cardiomyoblasts"],"prefix":"10.1139","volume":"94","author":[{"given":"Lei","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Cardiology, First Hospital of Jilin University, Changchun 130021, China."},{"name":"Department of Cardiology, Changchun Central Hospital, Changchun 130051, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, China\u2013Japan Union Hospital of Jilin University, Changchun 130033, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, First Hospital of Jilin University, Changchun 130021, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenguang","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junli","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Changchun Central Hospital, Changchun 130051, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengnan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Changchun Central Hospital, Changchun 130051, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, First Hospital of Jilin University, Changchun 130021, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-015-9625-4"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq339"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.6.1938"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001540"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2013.02.007"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.10.043"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0169"},{"issue":"2","key":"refg8\/ref8","first-page":"166","volume":"45","author":"Emekli-Alturfan E.","year":"2015","journal-title":"Ann. 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