{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:27:14Z","timestamp":1785450434875,"version":"3.56.0"},"reference-count":39,"publisher":"Canadian Science Publishing","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p> Piceatannol is a polyphenolic analog of resveratrol that selectively inhibits the non-receptor tyrosine kinase-Syk. This study investigates the potential ability of piceatannol to attenuate liver fibrosis and protect hepatocytes from injury. Thioacetamide was injected in adult male mice (100 mg\/kg, i.p., 3 times\/week) for 8 weeks. Piceatannol (1 or 5 mg\/kg per day) was administered by oral gavage during the last 4 weeks. Liver function biomarkers, tissue malondialdehyde (MDA), cytokeratin-18 (CK18), hepatocyte growth factor (HGF), and interleukin-10 (IL-10) were measured. Necroinflammation, fibrosis, expression of transforming growth factor (TGF)-\u03b2<jats:sub>1<\/jats:sub>, and \u03b1-smooth muscle actin (SMA) were scored by histopathological examination and immunohistochemistry. Obtained results showed ability of piceatannol (1 mg\/kg) to restore liver function and reduce inflammation. It significantly (p &lt; 0.001) reduced MDA, CK18, TGF-\u03b2<jats:sub>1<\/jats:sub>, and \u03b1-SMA expression, and increased HGF and IL-10. It can be concluded that piceatannol at low dose can inhibit TGF-\u03b2<jats:sub>1<\/jats:sub> induced hepatocytes apoptosis and exerts an anti-inflammatory effect attenuating fibrosis progression. <\/jats:p>","DOI":"10.1139\/cjpp-2016-0001","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T22:43:11Z","timestamp":1457217791000},"page":"779-787","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Piceatannol increases the expression of hepatocyte growth factor and IL-10 thereby protecting hepatocytes in thioacetamide-induced liver fibrosis"],"prefix":"10.1139","volume":"94","author":[{"given":"Hazem","family":"Abd-Elgawad","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashwa","family":"Abu-Elsaad","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"El-Karef","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20411"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1210\/mend.10.9.8885242"},{"key":"refg3\/ref3","first-page":"361","volume":"120","author":"Brenner D.A.","year":"2009","journal-title":"Trans. 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