{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:52:31Z","timestamp":1783385551753,"version":"3.54.6"},"reference-count":24,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p> Naringenin (Nari) has antioxidative and anti-atherosclerosis effects, and activation of ATP-sensitive potassium channel (K<jats:sub>ATP<\/jats:sub>) can offer cardiac protection. We hypothesized that Nari protects the heart against ischemia\u2013reperfusion (I\u2013R) injury through activation of K<jats:sub>ATP<\/jats:sub>. Isolated hearts from adult male Sprague-Dawley rats experienced a 30-min global ischemia followed by 60-min reperfusion (120 min for the infarct size determination). The hearts were treated with Nari (NARI); Nari plus glibenclamide (GLI), a non-specific ATP-sensitive potassium channel blocker (NARI+GLI); and Nari plus 5-hydroxy decanoic acid (5-HD), a mitochondrial membrane ATP-sensitive potassium channel blocker (NARI+5-HD). The left ventricular pressure, lactate dehydrogenates (LDH) in coronary effluent, superoxide dismutase (SOD) and malondialdehyde (MDA) in myocardium, and myocardial infarct area were measured. Nari above 2.5 \u03bcmol\/L improved the recovery of left ventricular function, decreased LDH in coronary effluent, and reduced myocardial infarct area. The SOD activity was increased and MDA was decreased in Nari-treated myocardium. The cardioprotective effect of Nari was canceled by GLI and 5-HD. In conclusion, Nari has a cardioprotective effect against I\u2013R injury, which may be carried out through activating ATP-sensitive potassium channels in both cell and mitochondrial membrane, and enhancing myocardial antioxidant capacity. <\/jats:p>","DOI":"10.1139\/cjpp-2016-0008","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T21:54:08Z","timestamp":1461102848000},"page":"973-978","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["The cardioprotective effect of naringenin against ischemia\u2013reperfusion injury through activation of ATP-sensitive potassium channel in rat"],"prefix":"10.1139","volume":"94","author":[{"given":"Li-Min","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Shijiazhuang 050017, PR China."},{"name":"Second Department of Cardiology, General Hospital of FengFeng Branch in Center Hebei Energy Sources Group, Handan 056200, PR China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Jie","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Shijiazhuang 050017, PR China."},{"name":"Hebei Collaborative Innovation Center for Cardio-cerebrovascular Disease, Shijiazhuang, Hebei 050000, PR China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, PR China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Qian","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Shijiazhuang 050017, PR China."},{"name":"Shandong Zaozhuang Vocational College of Technology, Tengzhou, Shandong 277500, PR China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Shijiazhuang 050017, PR China."},{"name":"Hebei Collaborative Innovation Center for Cardio-cerebrovascular Disease, Shijiazhuang, Hebei 050000, PR China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000342481"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-015-0376-5"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512005594"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01363-7"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90257-7"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-012-0206-y"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-5614(03)00059-1"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-009-0054-6"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050956"},{"key":"refg24\/ref24","unstructured":"National Research Council. 2006. Guide for the care and use of laboratory animals. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Academy Press, Washington, D.C."},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2005.tb00158.x"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00030.2013"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.09.026"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.11.012"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200001000-00014"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000065603.09430.58"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.04.018"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.03.018"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1021\/jf203259h"},{"issue":"5","key":"refg19\/ref19","first-page":"647","volume":"117","author":"Wei K.","year":"2004","journal-title":"Chin. Med. J. (Engl.)"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.10.003"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2816"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2013.02.001"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.02.025"}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/cjpp-2016-0008","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/cjpp-2016-0008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T14:02:09Z","timestamp":1751464929000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/cjpp-2016-0008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1139\/cjpp-2016-0008"],"URL":"https:\/\/doi.org\/10.1139\/cjpp-2016-0008","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"2016-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}