{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:53:17Z","timestamp":1787064797103,"version":"build-2736575974"},"reference-count":44,"publisher":"Canadian Science Publishing","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>\n                    Rhus tripartitum D.C., Anacardiaceae, has traditionally been used in Tunisia against many illnesses. The present study investigates, for the first time, the protective effects of the methanol extract of Rhus tripartitum fruit (MERT) against CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced hepatotoxicity and cisplatin-induced nephrotoxicty in Wistar rats. ALT, AST, LDH, GGT, creatinin, urea, and uric acid levels were studied. The changes in antioxidant parameters such as malondialdehyde (MDA) and protein carbonyl contents were also determined. The increased levels of MDA (30.97 and 11.50 nmol MDA\/mg protein in liver and kidney, respectively) and protein carbonyls (13.4 and 17.95 nmol\/mg protein in liver and kidney, respectively) were attenuated by MERT pretreatment (19.35 and 6.1 nmol MDA\/mg protein and 9.15 and 12 nmol\/mg protein in liver and kidney, respectively). The MERT pretreatment significantly reduced the increased biochemical parameters of liver and kidney caused by CCl\n                    <jats:sub>4<\/jats:sub>\n                    and cisplatin treatment. The histopathologic observation showed that MERT pretreatment restores the altered tissues. The observed results could be due to the high phenolic content and to MERT\u2019s important antioxidant potential. This study supports the hepatoprotective and nephroprotective effects of R. tripartitum.\n                  <\/jats:p>","DOI":"10.1139\/cjpp-2016-0029","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T17:46:52Z","timestamp":1460483212000},"page":"801-807","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Effects of\n                    <i>Rhus tripartitum<\/i>\n                    fruit extract on CCl\n                    <sub>4<\/sub>\n                    -induced hepatotoxicity and cisplatin-induced nephrotoxicity in rats"],"prefix":"10.1139","volume":"94","author":[{"given":"Nizar","family":"Tlili","sequence":"first","affiliation":[{"name":"D\u00e9partement de Biologie, Facult\u00e9 des Sciences de Tunis, Universit\u00e9 Tunis El-Manar, 2092 Tunis, Tunisia."},{"name":"Institut National de Recherches en G\u00e9nie Rural, Eaux et For\u00eats, Universit\u00e9 de Carthage, BP 10, Ariana 2080, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouar","family":"Feriani","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Biochimie Macromol\u00e9culaire et G\u00e9n\u00e9tique, Facult\u00e9 des Sciences de Gafsa, cit\u00e9 Zarroug, Universit\u00e9 de Gafsa, 2112 Tunisia."},{"name":"Laboratoire d\u2019Ecophysiologie Animale, Facult\u00e9 des Sciences de Sfax, 3018, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Salah","family":"Allagui","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Ecophysiologie Animale, Facult\u00e9 des Sciences de Sfax, 3018, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezzeddine","family":"Saadoui","sequence":"additional","affiliation":[{"name":"Institut National de Recherches en G\u00e9nie Rural, Eaux et For\u00eats, Universit\u00e9 de Carthage, BP 10, Ariana 2080, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelhamid","family":"Khaldi","sequence":"additional","affiliation":[{"name":"Institut National de Recherches en G\u00e9nie Rural, Eaux et For\u00eats, Universit\u00e9 de Carthage, BP 10, Ariana 2080, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizar","family":"Nasri","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biologie, Facult\u00e9 des Sciences de Tunis, Universit\u00e9 Tunis El-Manar, 2092 Tunis, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2011.639072"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2013003"},{"key":"refg4\/ref4","first-page":"401","volume":"87","author":"Ansari R.A.","year":"1988","journal-title":"Indian J. 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