{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:12:35Z","timestamp":1751515955172,"version":"3.41.0"},"reference-count":40,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p> Spontaneously hypertensive rats (SHR) display autonomic imbalance and abnormal body temperature (Tb) adjustments. Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) modulates hypoxia-induced hypothermia, but its role in SHR thermoregulation is unknown. We tested the hypothesis that SHR display peculiar thermoregulatory response to hypoxia and that endogenous H<jats:sub>2<\/jats:sub>S overproduced in the caudal nucleus of the solitary tract (NTS) of SHR modulates this response. SHR and Wistar rats were microinjected into the fourth ventricle with aminooxyacetate (AOA, H<jats:sub>2<\/jats:sub>S-synthezing enzyme inhibitor) or sodium sulfide (Na<jats:sub>2<\/jats:sub>S, H<jats:sub>2<\/jats:sub>S donor) and exposed to normoxia (21% inspired O<jats:sub>2<\/jats:sub>) or hypoxia (10% inspired O<jats:sub>2<\/jats:sub>, 30 min). Tb was continuously measured, and H<jats:sub>2<\/jats:sub>S production rate was assessed in caudal NTS homogenates. In both groups, AOA, Na<jats:sub>2<\/jats:sub>S, or saline (i.e., control; 1 \u03bcL) did not affect euthermia. Hypoxia caused similar decreases in Tb in both groups. AOA presented a longer latency to potentiate hypoxic hypothermia in SHR. Caudal NTS H<jats:sub>2<\/jats:sub>S production rate was higher in SHR. We suggest that increased bioavailability of H<jats:sub>2<\/jats:sub>S in the caudal NTS of SHR enables the adequate modulation of excitability of peripheral chemoreceptor-activated NTS neurons that ultimately induce suppression of brown adipose tissue thermogenesis, thus accounting for the normal hypoxic hypothermia. <\/jats:p>","DOI":"10.1139\/cjpp-2016-0033","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T21:35:54Z","timestamp":1473197754000},"page":"157-162","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Involvement of endogenous central hydrogen sulfide (H<sub>2<\/sub>S) in hypoxia-induced hypothermia in spontaneously hypertensive rats"],"prefix":"10.1139","volume":"95","author":[{"given":"Jo\u00e3o Paulo J.","family":"Sabino","sequence":"first","affiliation":[{"name":"Dental School of Ribeir\u00e3o Preto, 14040-904, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato N.","family":"Soriano","sequence":"additional","affiliation":[{"name":"Division of Physiology and Biophysics, Department of Basic Life Sciences, Federal University of Juiz de Fora, 35020-220, Governador Valadares, MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto F.","family":"Donatti","sequence":"additional","affiliation":[{"name":"Dental School of Ribeir\u00e3o Preto, 14040-904, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Restrepo","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Dental School of Ribeir\u00e3o Preto, 14040-904, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Kwiatkoski","sequence":"additional","affiliation":[{"name":"Dental School of Ribeir\u00e3o Preto, 14040-904, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helo\u00edsa D.C.","family":"Francescato","sequence":"additional","affiliation":[{"name":"School of Medicine of Ribeir\u00e3o Preto, 14040-904, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terezila M.","family":"Coimbra","sequence":"additional","affiliation":[{"name":"School of Medicine of Ribeir\u00e3o Preto, 14040-904, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz G.S.","family":"Branco","sequence":"additional","affiliation":[{"name":"Dental School of Ribeir\u00e3o Preto, 14040-904, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","volume":"16","author":"Abe K.","year":"1996","journal-title":"J. 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