{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:22:34Z","timestamp":1792801354947,"version":"4.5.0"},"reference-count":65,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p> This study was designed to investigate the effects of fisetin (FST) on hyperhomocysteinemia (HHcy)-induced experimental endothelial dysfunction (ED) and vascular dementia (VaD) in rats. Wistar rats were randomly divided into 8 groups: control, vehicle control, l-methionine, FST (5, 10, and 25 mg\/kg, p.o.), FST-per se (25 mg\/kg, p.o.), and donepezil (0.1 mg\/kg, p.o.). l-Methionine administration (1.7 g\/kg, p.o.) for 32 days induced HHcy. ED and VaD induced by HHcy were determined by vascular reactivity measurements, behavioral analysis using Morris water maze and Y-maze, along with a biochemical and histological evaluation of thoracic aorta and brain tissues. Administration of l-methionine developed behavioral deficits; triggered brain lipid peroxidation (LPO); compromised brain acetylcholinesterase activity (AChE); and reduced the levels of brain superoxide dismutase (SOD), brain catalase (CAT), brain reduced glutathione (GSH), and serum nitrite; and increased serum homocysteine and cholesterol levels. These effects were accompanied by decreased vascular NO bioavailability, marked intimal thickening of the aorta, and multiple necrotic foci in brain cortex. HHcy-induced alterations in the activities of SOD, CAT, GSH, AChE, LPO, behavioral deficits, ED, and histological aberrations were significantly attenuated by treatment with fisetin in a dose-dependent manner. Collectively, our results indicate that fisetin exerts endothelial and neuroprotective effects against HHcy-induced ED and VaD. <\/jats:p>","DOI":"10.1139\/cjpp-2016-0147","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T21:36:20Z","timestamp":1470951380000},"page":"32-42","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia"],"prefix":"10.1139","volume":"95","author":[{"given":"Boyina","family":"Hemanth Kumar","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Anurag Group of Institutions (Formerly Lalitha College of Pharmacy), Hyderabad, Telangana, India."},{"name":"Center for Pharmaceutical Sciences and Research and Development Cell, Jawaharlal Nehru Technological University, Hyderabad, Telangana, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravula","family":"Arun Reddy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Anurag Group of Institutions (Formerly Lalitha College of Pharmacy), Hyderabad, Telangana, India."},{"name":"Graduate School of Biomedical Sciences, Rowan University, Stratford, NJ 08084, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerald","family":"Mahesh Kumar","sequence":"additional","affiliation":[{"name":"Animal House Facility, CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad, Telangana 500007, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Dinesh Kumar","sequence":"additional","affiliation":[{"name":"National Institute of Nutrition (ICMR), Food & Drug Toxicology Research Centre (FDTRC), Hyderabad, Telangana 500007, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash V.","family":"Diwan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Anurag Group of Institutions (Formerly Lalitha College of Pharmacy), Hyderabad, Telangana, India."},{"name":"Maratha Mandal Central Research Laboratory, Belagavi-590010, Karnataka, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2007.01.004"},{"issue":"9","key":"refg2\/ref2","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1093\/jn\/130.9.2243","volume":"130","author":"Arai Y.","year":"2000","journal-title":"J. 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