{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:38:01Z","timestamp":1787017081287,"version":"build-2736575974"},"reference-count":38,"publisher":"Canadian Science Publishing","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>\n                    To explore hepatoprotective role and underlying mechanisms of Trillium tschonoskii Maxim (TTM), 36 rats were randomly divided into control, CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced liver injury model, and biphenyl dimethyl dicarboxylate (DDB) and low-, moderate-, and high-dose TTM treatment groups. After CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced model establishment, the rats from DDB and TTM groups were administrated with DDB at 0.2 g\/kg per day and TTM at 0.1, 0.5, and 1.0 g\/kg per day, while the rats from control and model groups were administrated with saline. After 5 days of treatments, all rats were sacrificed for determining serum ALT and AST levels and liver index, examining histopathological changes in liver through HE and TUNEL staining, and evaluating TNF-\u03b1 and IL-6 mRNA expression by real-time PCR, and caspase-3, Bcl-2, and Bax expression by Western blot. Results indicated that CCl\n                    <jats:sub>4<\/jats:sub>\n                    could induce acute liver injury and abnormal liver function in rats with obvious hepatomegaly, increased liver index, high ALT and AST levels, up-regulated TNF-\u03b1 and IL-6, and overexpressed Bax and caspase-3. However, DDB and TTM could execute protective role in CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced liver injury in rats through reducing ALT and AST levels, rescuing hepatomegaly, down-regulating inflammatory factors and inhibiting hepatocyte apoptosis in a dose-dependent manner. Therefore, TTM has obvious protective role in CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced liver injury of rats through inhibiting hepatocyte apoptosis.\n                  <\/jats:p>","DOI":"10.1139\/cjpp-2016-0228","type":"journal-article","created":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T17:34:49Z","timestamp":1467653689000},"page":"1291-1297","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Protective effect of\n                    <i>Trillium tschonoskii<\/i>\n                    saponin on CCl\n                    <sub>4<\/sub>\n                    -induced acute liver injury of rats through apoptosis inhibition"],"prefix":"10.1139","volume":"94","author":[{"given":"Hao","family":"Wu","sequence":"first","affiliation":[{"name":"College of Science and Technology of Hubei University for Nationalities, Enshi 445000, China."},{"name":"College of Medicine, Hubei University for Nationalities, Enshi 445000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Qiu","sequence":"additional","affiliation":[{"name":"College of Medicine, Hubei University for Nationalities, Enshi 445000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Shu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan 430079, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan 430079, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renpeng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Science and Technology of Hubei University for Nationalities, Enshi 445000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Liu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Hubei University for Nationalities, Enshi 445000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longquan","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Medicine, Hubei University for Nationalities, Enshi 445000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Medicine, Hubei University for Nationalities, Enshi 445000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Chen","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan 430079, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2572-2"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/356729"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e3282f6a450"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60274-7"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12366"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.11.2.14622"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.12.013"},{"key":"refg8\/ref8","unstructured":"Chen, Q. 1993. 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