{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:59:40Z","timestamp":1790611180739,"version":"4.1.0"},"reference-count":33,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p> The hypertrophic scar is a medical difficulty of humans, which has caused great pain to patients. Here, we investigated the inhibitory effect of miR-29b on scar formation. The scalded model was established in mice and miR-29b mimics or a negative control was subcutaneously injected into the injury skin. Then various molecular biological experiments were performed to assess the effect of miR-29b on scar formation. According to our present study, first, the results demonstrated that miR-29b was down-regulated in thermal injury tissue and miR-29b treatment could promote wound healing, inhibit scar formation, and alleviate histopathological morphologic alteration in scald tissues. Additionally, miR-29b treatment suppressed collagen deposition and fibrotic gene expression in scar tissues. Finally, we found that miR-29b treatment inhibited the TGF-\u03b21\/Smad\/CTGF signaling pathway. Taken together, our data suggest that miR-29b treatment has an inhibitory effect against scar formation via inhibition of the TGF-\u03b21\/Smad\/CTGF signaling pathway and may provide a potential molecular basis for future treatments for hypertrophic scars. <\/jats:p>","DOI":"10.1139\/cjpp-2016-0248","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T22:34:54Z","timestamp":1480026894000},"page":"437-442","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":64,"title":["miR-29b promotes skin wound healing and reduces excessive scar formation by inhibition of the TGF-\u03b21\/Smad\/CTGF signaling pathway"],"prefix":"10.1139","volume":"95","author":[{"given":"Jingdong","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, 71 Xinmin Avenue, Changchun 130021, People\u2019s Republic of China."},{"name":"Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, 71 Xinmin Avenue, Changchun 130021, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, 71 Xinmin Avenue, Changchun 130021, People\u2019s Republic of China."},{"name":"Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, 71 Xinmin Avenue, Changchun 130021, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, 71 Xinmin Avenue, Changchun 130021, People\u2019s Republic of China."},{"name":"Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, 71 Xinmin Avenue, Changchun 130021, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, 71 Xinmin Avenue, Changchun 130021, People\u2019s Republic of China."},{"name":"Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, 71 Xinmin Avenue, Changchun 130021, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, 71 Xinmin Avenue, Changchun 130021, People\u2019s Republic of China."},{"name":"Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, 71 Xinmin Avenue, Changchun 130021, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.20.15220"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.21.6.3719"},{"key":"refg3\/ref3","first-page":"121098","volume":"2014","author":"Al-Qattan M.M.","year":"2014","journal-title":"Biomed. 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