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Therefore, in this study, we tested the interactive effects of cannabinoid and vanilloid systems on learning and memory in rats by using passive avoidance learning (PAL) tests. Forty male Wistar rats were divided into the following 4 groups: (1) control (DMSO+saline), (2) WIN55,212\u20132, (3) capsaicin, and (4) WIN55,212\u20132 + capsaicin. On test day, capsaicin, a vanilloid receptor type 1 (TRPV1) agonist, or WIN55,212\u20132, a cannabinoid receptor (CB<jats:sub>1<\/jats:sub>\/CB<jats:sub>2<\/jats:sub>) agonist, or both substances were injected intraperitoneally. Compared to the control group, the group treated with capsaicin (TRPV1 agonist) had better scores in the PAL acquisition and retention test, whereas treatment with WIN55,212\u20132 (CB<jats:sub>1<\/jats:sub>\/CB<jats:sub>2<\/jats:sub> agonist) decreased the test scores. Capsaicin partly reduced the effects of WIN55,212\u20132 on PAL and memory. We conclude that the acute administration of a TRPV1 agonist improves the rats\u2019 cognitive performance in PAL tasks and that a vanilloid-related mechanism may underlie the agonistic effect of WIN55,212\u20132 on learning and memory. <\/jats:p>","DOI":"10.1139\/cjpp-2016-0274","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T21:34:52Z","timestamp":1478122492000},"page":"382-387","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Effects of cannabinoid and vanilloid receptor agonists and their interaction on learning and memory in rats"],"prefix":"10.1139","volume":"95","author":[{"given":"Mariam","family":"Shiri","sequence":"first","affiliation":[{"name":"Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran."},{"name":"Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Komaki","sequence":"additional","affiliation":[{"name":"Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrbanoo","family":"Oryan","sequence":"additional","affiliation":[{"name":"Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoumeh","family":"Taheri","sequence":"additional","affiliation":[{"name":"Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamidreza","family":"Komaki","sequence":"additional","affiliation":[{"name":"Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farshid","family":"Etaee","sequence":"additional","affiliation":[{"name":"Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"issue":"10","key":"refg1\/ref1","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1002\/hipo.20711","volume":"20","author":"Abush H.","year":"2010","journal-title":"Hippocampus"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(01)00145-9"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2015.06.004"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2015.02.005"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(94)90101-5"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2494"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00821-8"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.05.018"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(11)70578-3"},{"issue":"8","key":"refg10\/ref10","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nn879","volume":"5","author":"Carlson G.","year":"2002","journal-title":"Nat. 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