{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:27:20Z","timestamp":1761744440069,"version":"3.43.0"},"reference-count":83,"publisher":"Canadian Science Publishing","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p> Gabapentin as an anticonvulsant drug also has beneficial effects in treatment of depression. Previously, we showed that acute administration of gabapentin produced an antidepressant-like effect in the mouse forced swimming test (FST) by a mechanism that involves the inhibition of nitric oxide (NO). Considering the involvement of NO in adenosine triphosphate (ATP)-sensitive potassium channels (K<jats:sub>ATP<\/jats:sub>), in the present study we investigated the involvement of K<jats:sub>ATP<\/jats:sub> channels in antidepressant-like effect of gabapentin. Gabapentin at different doses (5\u201310 mg\/kg) and fluoxetine (20 mg\/kg) were administrated by intraperitoneal route, 60 and 30 min, respectively, before the test. To clarify the probable involvement of K<jats:sub>ATP<\/jats:sub> channels, mice were pretreated with K<jats:sub>ATP<\/jats:sub> channel inhibitor or opener. Gabapentin at dose 10 mg\/kg significantly decreased the immobility behavior of mice similar to fluoxetine (20 mg\/kg). Co-administration of subeffective dose (1 mg\/kg) of glibenclamide (inhibitor of K<jats:sub>ATP<\/jats:sub> channels) with gabapentin (3 mg\/kg) showed a synergistic antidepressant-like effect. Also, subeffective dose of cromakalim (opener of K<jats:sub>ATP<\/jats:sub> channels, 0.1 mg\/kg) inhibited the antidepressant-like effect of gabapentin (10 mg\/kg). None of the treatments had any impact on the locomotor movement. Our study, for the first time, revealed that antidepressant-like effect of gabapentin in mice is mediated by blocking the K<jats:sub>ATP<\/jats:sub> channels. <\/jats:p>","DOI":"10.1139\/cjpp-2016-0292","type":"journal-article","created":{"date-parts":[[2017,1,29]],"date-time":"2017-01-29T17:42:06Z","timestamp":1485711726000},"page":"795-802","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Possible involvement of ATP-sensitive potassium channels in the antidepressant-like effects of gabapentin in mouse forced swimming test"],"prefix":"10.1139","volume":"95","author":[{"given":"Sattar","family":"Ostadhadi","sequence":"first","affiliation":[{"name":"Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran."},{"name":"Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyhaneh","family":"Akbarian","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran."},{"name":"Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Norouzi-Javidan","sequence":"additional","affiliation":[{"name":"Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahid","family":"Nikoui","sequence":"additional","affiliation":[{"name":"Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Zolfaghari","sequence":"additional","affiliation":[{"name":"Department of Tissue Engineering and Applied Cell Sciences, Iran University of Medical Sciences, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Chamanara","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran."},{"name":"Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad-Reza","family":"Dehpour","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran."},{"name":"Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2305257"},{"issue":"2","key":"refg2\/ref2","doi-asserted-by":"crossref","first-page":"H423","DOI":"10.1152\/ajpheart.1996.270.2.H423","volume":"270","author":"Armstead W.","year":"1996","journal-title":"Am. 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