{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T16:46:38Z","timestamp":1777221998910,"version":"3.51.4"},"reference-count":26,"publisher":"Canadian Science Publishing","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p> There is increasing evidence for a beneficial effect of ginseng on cardiac pathology. Here, we determined whether North American ginseng can modulate the deleterious effects of the \u03b2-adrenoceptor agonist isoproterenol on cardiac hypertrophy and function using in vitro and in vivo approaches. Isoproterenol was administered for 2 weeks at either 25 mg\/kg per day or 50 mg\/kg per day (ISO25 or ISO50) via a subcutaneously implanted osmotic mini-pump to either control rats or those receiving ginseng (0.9 g\/L in the drinking water ad libitum). Isoproterenol produced time- and dose-dependent left ventricular dysfunction, although these effects were attenuated by ginseng. Improved cardiac functions were associated with reduced heart masses, as well as prevention in the upregulation of the hypertrophy-related fetal gene expression. Lung masses were similarly attenuated, suggesting reduced pulmonary congestion. In in vitro studies, ginseng (10 \u03bcg\/mL) completely suppressed the hypertrophic response to 1 \u03bcmol\/L isoproterenol in terms of myocyte surface area, as well as reduction in the upregulation of fetal gene expression. These effects were associated with attenuation in both protein kinase A and cAMP response element-binding protein phosphorylation. Ginseng attenuates adverse cardiac adrenergic responses and, therefore, may be an effective therapy to reduce hypertrophy and heart failure associated with excessive catecholamine production. <\/jats:p>","DOI":"10.1139\/cjpp-2016-0337","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T17:36:33Z","timestamp":1471455393000},"page":"1325-1335","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["North American ginseng (<i>Panax quinquefolius<\/i>) suppresses \u03b2-adrenergic-dependent signalling, hypertrophy, and cardiac dysfunction"],"prefix":"10.1139","volume":"94","author":[{"given":"Xilan","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada."},{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong Tracey","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada."},{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatesh","family":"Rajapurohitam","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada."},{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy Xiaoling","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada."},{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada."},{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund M.K.","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada."},{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Karmazyn","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada."},{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1139\/Y09-042"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00212-9"},{"issue":"3","key":"refg3\/ref3","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1152\/jappl.2001.90.3.1088","volume":"90","author":"Azzam Z.S.","year":"2001","journal-title":"J. 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