{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:41:33Z","timestamp":1787017293700,"version":"build-2736575974"},"reference-count":23,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Resveratrol, a natural compound found in over 70 plants, is known to possess immunoregulatory effects and anti-inflammatory activity. It has been shown that resveratrol has regulatory effects on different signaling pathways in different diseases. However, few reports have evaluated the effects of resveratrol on reinforcing immunity recovery via activating nuclear factor-\u03baB (NF-\u03baB) pathway and Jun N-terminal kinases (JNK) pathway. The present study aimed to assess immune-enhancing activity and underlying mechanism of resveratrol in immunosuppressive mice. Previously, we reported that resveratrol could promote mouse spleen lymphocyte functions to recover the immune system effectively. In the present study, we show that resveratrol could upregulate the expressions of NF-\u03baB, I\u03baB kinase, JNK, and c-jun in splenic lymphocytes of immunosuppressive mice. Taken together, our results indicate that resveratrol could promote recovery of immunologic function in immunosuppressive mice by activating JNK\/NF-\u03baB pathway.<\/jats:p>","DOI":"10.1139\/cjpp-2016-0404","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T20:55:36Z","timestamp":1494968136000},"page":"763-767","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Resveratrol promotes recovery of immune function of immunosuppressive mice by activating JNK\/NF-\u03baB pathway in splenic lymphocytes"],"prefix":"10.1139","volume":"95","author":[{"given":"Xin","family":"Lai","sequence":"first","affiliation":[{"name":"Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Cao","sequence":"additional","affiliation":[{"name":"Core Laboratory, Sichuan Provincial People\u2019s Hospital, Chengdu, 610072, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Song","sequence":"additional","affiliation":[{"name":"Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renyong","family":"Jia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfeng","family":"Zou","sequence":"additional","affiliation":[{"name":"Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Li","sequence":"additional","affiliation":[{"name":"Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Liang","sequence":"additional","affiliation":[{"name":"Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changliang","family":"He","sequence":"additional","affiliation":[{"name":"Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizi","family":"Yin","sequence":"additional","affiliation":[{"name":"Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guizhou","family":"Yue","sequence":"additional","affiliation":[{"name":"College of Science, Sichuan Agricultural University, Ya\u2019an, 625014, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Ye","sequence":"additional","affiliation":[{"name":"Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiong","family":"Yin","sequence":"additional","affiliation":[{"name":"Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122759"},{"issue":"1","key":"refg2\/ref2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4049\/jimmunol.149.1.83","volume":"149","author":"Arima N.","year":"1992","journal-title":"J. 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