{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:45:59Z","timestamp":1787881559829,"version":"build-2784847793"},"reference-count":43,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p> This study investigated the gastroprotective effects of N-acetylcysteine (NAC) against indomethacin-induced gastric ulcer in rats. Ulceration was induced by a single oral administration of indomethacin (30 mg\/kg). 50 male albino rats were allocated into 5 equal groups: control group received normal saline orally, indomethacin group rats received normal saline orally for 5 days and indomethacin (50 mg\/kg) on the last day, ranitidine group received ranitidine (reference drug) orally for 5 days (50 mg\/kg) before receiving indomethacin (50 mg\/kg) on the last day, and NAC groups received NAC orally at 300 and 500 mg\/kg, respectively, for 5 days before receiving indomethacin (50 mg\/kg) on the last day. Gastric tissue interleukin-1\u03b2 (IL-1\u03b2), interferon-\u03b3 (IFN-\u03b3), and caspase-3 levels were immunoassayed. Total thiol (T-SH), myeloperoxidase (MPO), and glucose-6-phosphate dehydrogenase (G6PD) were determined by spectrophotometry. Cytokine-induced neutrophil chemoattractant 2\u03b1 (CINC-2\u03b1) gene expression was evaluated in addition to Bcl-2 immunohistochemistry. Pretreatment with NAC improved the inflammatory, apoptotic, and redox status in a dose-dependent manner particularly in NAC 500 mg\/kg pretreated group. These results show a role for NAC in improving indomethacin-induced gastric ulceration via antioxidative, antiapoptotic, and anti-inflammatory interactive mechanisms. <\/jats:p>","DOI":"10.1139\/cjpp-2016-0442","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T22:35:16Z","timestamp":1479162916000},"page":"396-403","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["<i>N<\/i>-acetylcysteine a possible protector against indomethacin-induced peptic ulcer: crosstalk between antioxidant, anti-inflammatory, and antiapoptotic mechanisms"],"prefix":"10.1139","volume":"95","author":[{"given":"Nema Ali","family":"Soliman","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa Hussein","family":"Zineldeen","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Alaa","family":"Katary","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Damanhur University, Damanhur, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darin Abd","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Faculty of Medicine, Tanta University, Tanta, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.21232"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064751"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.09.020"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12202"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084400"},{"issue":"1","key":"refg6\/ref6","first-page":"109","volume":"25","author":"Cartier P.","year":"1967","journal-title":"Ann. 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