{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:38:05Z","timestamp":1778186285157,"version":"3.51.4"},"reference-count":45,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p> Drug-induced hepatotoxicity is one of the most commonly encountered obstacles in the field of medical practice. Sodium valproate (VPA) is among many drugs with reported hepatotoxic effects. Sulforaphane (SFN) is a thiol compound found in wide abundance in cruciferous plants that has numerous reported therapeutic efficacies. The current investigation sheds light on the potential hepatoprotective effect of SFN against VPA-induced liver injury in rats. Twice daily VPA (700 mg\/kg, i.p.) for 7 days induced significant biochemical alterations and hepatic histopathological damage. SFN (0.5 mg\/kg, orally) for 7 days significantly boosted liver function biomarkers; it reduced serum alanine transaminase, aspartate aminotransferase, and alkaline phosphatase, and restored serum albumin concentration in a significant manner. Meanwhile, SFN significantly mitigated VPA-induced histopathological alterations. To highlight the mechanisms implicated in the observed hepatoprotective action, hepatic malondialdehyde and tumour necrosis factor \u03b1 content significantly declined with concomitant increase in hepatic heme oxygenase-1 content and glutathione concentration with SFN treatment. In conclusion, SFN can significantly ameliorate VPA-induced hepatotoxicity and liver injury primarily by direct association between antioxidant and anti-inflammatory properties. <\/jats:p>","DOI":"10.1139\/cjpp-2016-0447","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T21:37:01Z","timestamp":1478036221000},"page":"420-426","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Sulforaphane protects against sodium valproate\u2013induced acute liver injury"],"prefix":"10.1139","volume":"95","author":[{"given":"Entsar A.","family":"Nazmy","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Mansoura University, Mansoura, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar A.","family":"El-Khouly","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Mansoura University, Mansoura, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoda","family":"Atef","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mansoura University, Mansoura, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman","family":"Said","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Mansoura University, Mansoura, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"issue":"3","key":"refg1\/ref1","first-page":"685","volume":"3","author":"Akhondian J.","year":"2015","journal-title":"Int. J. Pediatr."},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2012.05.003"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c120011"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13011"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(78)52032-6"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.012"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-014-9604-y"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28844"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.2174\/1872214809666150505164138"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.112203099"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i9.1251"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300556"},{"key":"refg13\/ref13","first-page":"272","volume":"57","author":"Gerh\u00e4user C.","year":"1997","journal-title":"Cancer Res."},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.09.017"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2010.11.005"},{"key":"refg16\/ref16","unstructured":"Guide for the Care and Use of Laboratory Animals. 1996. National Academy Press, Washington, DC, USA."},{"key":"refg17\/ref17","doi-asserted-by":"publisher","unstructured":"Harvey, C.J., Thimmulappa, R.K., Sethi, S., Kong, X., Yarmus, L., Brown, R.H., et al. 2011. Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model. Sci. Transl. Med. 3: 78ra32. 10.1126\/scitranslmed.3002042. 21490276.","DOI":"10.1126\/scitranslmed.3002042"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3221"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051047"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104794200"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(02)00282-6"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.11.050"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.1.680"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80226-6"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840010511"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.4106"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2007.09.014"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.12.018"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.10.002"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.07.036"},{"key":"refg31\/ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2007.11.006"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114186"},{"key":"refg33\/ref33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.33590\/emjhepatol\/10313515","volume":"1","author":"Privitera G.","year":"2014","journal-title":"EMJ Hepatol."},{"issue":"4","key":"refg34\/ref34","first-page":"257","volume":"23","author":"Pyleris E.","year":"2010","journal-title":"Ann. Gastroenterol."},{"key":"refg35\/ref35","first-page":"96","volume":"9","author":"Sadeghi Niaraki M.","year":"2013","journal-title":"J. Stress Physiol. Biochem."},{"key":"refg36\/ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-011-0117-1"},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2015-0270"},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-008-0841-x"},{"key":"refg39\/ref39","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2009.127"},{"key":"refg40\/ref40","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1042\/bj2940719","volume":"294","author":"Takeyama N.","year":"1993","journal-title":"Biochem. J."},{"key":"refg41\/ref41","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i35.4669"},{"key":"refg42\/ref42","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-013-9548-5"},{"key":"refg43\/ref43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138771"},{"key":"refg44\/ref44","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21095"},{"key":"refg45\/ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.09.018"}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/cjpp-2016-0447","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/cjpp-2016-0447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T19:46:11Z","timestamp":1751485571000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/cjpp-2016-0447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1139\/cjpp-2016-0447"],"URL":"https:\/\/doi.org\/10.1139\/cjpp-2016-0447","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"2016-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}