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Because hepatic steatosis and injury are also commonly induced by hepatotoxin, the aim of the present study is to clarify whether CNTF could alleviate hepatic steatosis and injury induced by carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>). Unexpectedly, when combined with CCl<jats:sub>4<\/jats:sub>, CNTF aggravated hepatic steatosis and liver injury. The mechanism is associated with effects of CNTF that inhibited lipoprotein secretion and drastically impaired the ability of lipoproteins to act as transport vehicles for lipids from the liver to the circulation. While injected after CCl<jats:sub>4<\/jats:sub> cessation, CNTF could improve liver function. These data suggest that CNTF could be a potential hepatoprotective agent against CCl<jats:sub>4<\/jats:sub>-induced hepatic injury after the cessation of CCl<jats:sub>4<\/jats:sub> exposure. However, it is forbidden to combine recombinant mutant of human CNTF treatment with CCl<jats:sub>4<\/jats:sub>. <\/jats:p>","DOI":"10.1139\/cjpp-2016-0564","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T22:34:33Z","timestamp":1481236473000},"page":"620-623","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Ciliary neurotrophic factor analogue aggravates CCl<sub>4<\/sub>-induced acute hepatic injury in rats"],"prefix":"10.1139","volume":"95","author":[{"given":"Ming-Xia","family":"Cui","sequence":"first","affiliation":[{"name":"Institute of Pharmacology, School of Basic Medical Science, Lanzhou University; Key Laboratory of Preclinical Study for New Drug of Gansu Province, Lanzhou 730000, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Feng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Gansu Provincial Cancer Hospital, Lanzhou 730050, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Ning","family":"Min","sequence":"additional","affiliation":[{"name":"The First Hospital of Lanzhou University, Lanzhou 730000, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[{"name":"Dingxi District of Gansu University of Chinese Medicine, Dingxi 743000, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, School of Basic Medical Science, Lanzhou University; Key Laboratory of Preclinical Study for New Drug of Gansu Province, Lanzhou 730000, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1515\/znc-2001-3-419","volume":"56","author":"Boll M.","year":"2001","journal-title":"Z. 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