{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:11:20Z","timestamp":1760267480694,"version":"3.43.0"},"reference-count":31,"publisher":"Canadian Science Publishing","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p> Tumor necrosis factor-alpha (TNF-\u03b1) is a pivotal mediator that triggers inflammatory process, oxidative stress, and multiple organ injury in sepsis. We investigated the effects of infliximab on survival, mesenteric artery blood flow (MBF), vascular reactivity, and oxidative and inflammatory injuries in cecal ligation and puncture (CLP)-induced sepsis. Wistar rats were divided into Sham, CLP, Sham+infliximab, and CLP+infliximab subgroups. Twenty-four hours before the operations, rats were injected intraperitoneally with infliximab (7 mg\/kg) or vehicle (saline; 1 mL\/kg). Twenty hours after the operations, MBF and phenylephrine responses of isolated aortic rings were measured. Tissue damages were examined biochemically and histopathologically. Furthermore, survival rates were monitored throughout 96 h. Infliximab improved survival, mesenteric perfusion, and aortic function after CLP. Increases of serum AST, ALT, LDH, BUN, Cr, and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6) induced by CLP were blocked by infliximab. Infliximab prevented malondialdehyde elevations in septic liver, lung, spleen, and kidney tissues, as well as glutathione reductions in septic liver, spleen, and kidney tissues. Protective effects of infliximab on multiple organ damage were also observed histopathologically. Infliximab showed protective effects in sepsis due to its improvement effects on mesenteric perfusion, aortic function, and its anti-inflammatory and antioxidative effects. <\/jats:p>","DOI":"10.1139\/cjpp-2016-0628","type":"journal-article","created":{"date-parts":[[2017,4,29]],"date-time":"2017-04-29T17:36:50Z","timestamp":1493487410000},"page":"866-872","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Infliximab alleviates the mortality, mesenteric hypoperfusion, aortic dysfunction, and multiple organ damage in septic rats"],"prefix":"10.1139","volume":"95","author":[{"given":"Erdem Kamil","family":"Ozer","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Selcuk University, Konya, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Tugrul","family":"Goktas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Kilinc","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysun","family":"Toker","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hulagu","family":"Bariskaner","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Selcuk University, Konya, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ceyhan","family":"Ugurluoglu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Selcuk University, Konya, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper Bektas","family":"Iskit","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-015-0224-z"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.04933.x"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.4161\/viru.26482"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2769-8"},{"issue":"2","key":"refg5\/ref5","doi-asserted-by":"crossref","first-page":"E58","DOI":"10.25011\/cim.v37i2.21087","volume":"37","author":"Duran-Bedolla J.","year":"2014","journal-title":"Clin. 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