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A recent study showed that patients with diabetes mellitus treated with mineralocorticoid receptor antagonists have improved coronary microvascular function, leading to improved diastolic dysfunction. In this study, we evaluated the influence of acute administration of spironolactone on myocardial function in rats with streptozotocin-induced diabetes mellitus, with special emphasis on cardiodynamic parameters in diabetic rat hearts. The present study was carried out on 40 adult male Wistar albino rats (8 weeks old). Rats were randomly divided into 4 groups (10 animals per group): healthy rats treated with 0.1 \u03bcmol\/L of spironolactone, diabetic rats treated with 0.1 \u03bcmol\/L of spironolactone, healthy rats treated with 3 \u03bcmol\/L of spironolactone, and diabetic rats treated with 3 \u03bcmol\/L of spironolactone. Different, dose-dependent, acute responses of spironolactone treatment on isolated, working diabetic and healthy rat heart were observed in our study. In healthy rats, better systolic function was achieved with higher spironolactone dose, while in diabetic rats, similar effects of low and high spironolactone dose were observed. <\/jats:p>","DOI":"10.1139\/cjpp-2017-0055","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T21:37:35Z","timestamp":1501105055000},"page":"1343-1350","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The acute effects of different spironolactone doses on cardiac function in streptozotocin-induced diabetic rats"],"prefix":"10.1139","volume":"95","author":[{"given":"Aleksandra","family":"Vranic","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Simovic","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology, Clinical Center Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petar","family":"Ristic","sequence":"additional","affiliation":[{"name":"Clinic of Endocrinology, Military Medical Academy, Belgrade, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Nikolic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isidora","family":"Stojic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Srejovic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac 34000, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Zivkovic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac 34000, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Jakovljevic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac 34000, Serbia."},{"name":"1st Moscow State Medical, Department of Human Pathology, University IM Sechenov, Moscow, Russia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dusan","family":"Djuric","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.03.046"},{"issue":"1","key":"refg2\/ref2","first-page":"150","volume":"166","author":"Bacciarelli C.","year":"1967","journal-title":"Arch. 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