{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:09:40Z","timestamp":1760299780069,"version":"3.41.0"},"reference-count":53,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p> Metformin (MET) is widely used in the correction of insulin (INS) resistance and metabolic abnormalities in type 2 diabetes. However, its effect on INS resistance and metabolic disorders associated with cancer cachexia is not established. We investigated the MET effects, isolated or associated with INS, on INS resistance and metabolic changes induced by Walker-256 tumor in rats with advanced cachexia. MET (500 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>, oral) and MET + INS (1.0 IU\u00b7kg<jats:sup>\u22121<\/jats:sup>, s.c.) were administered for 12 days, starting on the day of tumor cell inoculation. Tumor-bearing rats showed adipose and muscle mass wasting, body mass loss, anorexia, decreased Akt phosphorylation in retroperitoneal and mesenteric adipose tissue, peripheral INS resistance, hypoinsulinemia, reduced INS content and secretion from pancreatic islets, and also inhibition of glycolysis, gluconeogenesis, and glycogenolysis in liver. MET and MET + INS treatments did not prevent these changes. It can be concluded that treatments with MET and MET + INS did not prevent the adipose and muscle mass wasting and body mass loss of tumor-bearing rats possibly by not improving INS resistance. Therefore, MET, used for the treatment of INS resistance in type 2 diabetes, is not effective in improving INS resistance in the advanced stage of cancer cachexia, evidencing that the drug does not have the same beneficial effect in these 2 diseases. <\/jats:p>","DOI":"10.1139\/cjpp-2017-0171","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T22:35:34Z","timestamp":1515191734000},"page":"498-505","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of metformin on insulin resistance and metabolic disorders in tumor-bearing rats with advanced cachexia"],"prefix":"10.1139","volume":"96","author":[{"given":"Flaviane","family":"de Fatima Silva","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milene","family":"Ortiz-Silva","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winny Beatriz de Souza","family":"Galia","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila","family":"Cassolla","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francemilson Goulart","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of S\u00e3o Paulo, 05508-900, S\u00e3o Paulo, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Fernanda Rodrigues","family":"Graciano","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo Rafael","family":"Carpinelli","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of S\u00e3o Paulo, 05508-900, S\u00e3o Paulo, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helenir Medri","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.09.022"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.10.003"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24784"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3099"},{"key":"refg5\/ref5","unstructured":"Bergmeyer, H., and Bernt, E. 1974. 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