{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:28:37Z","timestamp":1790116117622,"version":"4.0.1"},"reference-count":50,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p> The present research studied the influence of zinc oxide nanoparticles (ZnO-NPs; 5, 7.5, and 10 mg\/kg, i.p.) on the liver and kidney injuries motivated by thioacetamide (TAA; 100 mg\/kg, i.p.). Each treatment was carried out 3 times per week for 8 weeks. ZnO-NPs relieved the decrease of hepatic or renal reduced glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) induced by TAA. Moreover, ZnO-NPs lowered tissue malondialdehyde (MDA, an indicator for lipid peroxidation). TAA treatment led to a significant increase in plasma inflammatory markers (TNF-\u03b1, IL-6), liver enzymes (gamma-glutamyltransferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and kidney function parameters (creatinine, urea, uric acid). However, these parameters were reduced after treatment with ZnO-NPs. In addition, the hepatic fibrosis markers, hydroxyproline level, and \u03b1-smooth muscle actin immunopositive stain were lowered by ZnO-NPs. The protective effect of ZnO-NPs in respect to biochemical changes was also confirmed by histopathological and immunohistochemistry studies in the liver and kidney sections. Our results suggested that ZnO-NPs may attenuate TAA toxicity via suppression of oxidative stress. <\/jats:p>","DOI":"10.1139\/cjpp-2017-0247","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T21:35:42Z","timestamp":1502919342000},"page":"337-344","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":68,"title":["Role of zinc oxide nanoparticles in alleviating hepatic fibrosis and nephrotoxicity induced by thioacetamide in rats"],"prefix":"10.1139","volume":"96","author":[{"given":"Samir A.E.","family":"Bashandy","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Medical Division, National Research Centre, 33 EL Bohouth St. (former EL Tahir St.), Dokki, Giza, Egypt. P.O.12622."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz","family":"Alaamer","sequence":"additional","affiliation":[{"name":"Committee of Radiation and Environmental Pollution Protection (CREPP), Department of Physics, College of Science, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif A. 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P.O.12622."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2015.06.010"},{"key":"refg2\/ref2","first-page":"1","volume":"154","author":"Agren M.S.","year":"1990","journal-title":"Acta Derm.-Venereol., Suppl."},{"issue":"2","key":"refg3\/ref3","first-page":"54","volume":"3","author":"Ali H.S.","year":"2016","journal-title":"Eur. J. Pharm. Med. Res."},{"issue":"5","key":"refg4\/ref4","first-page":"353","volume":"11","author":"Badkoobeh P.","year":"2013","journal-title":"Iran. J. Reprod. Med."},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.14712\/18059694.2015.94"},{"key":"refg6\/ref6","doi-asserted-by":"crossref","unstructured":"Bao, B., Ahmad, A., Azmi, A., Li, Y., Prasad, A., and Sarkar, F.H. 2013. The biological significance of zinc in inflammation and aging. In Inflammation, advancing age and nutrition: research and clinical interventions. 1st ed. 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