{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T10:15:22Z","timestamp":1780654522920,"version":"3.54.1"},"reference-count":31,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p> The aim of this study was to evaluate the potential effects of 2,3,4\u2032,5-tetrahydroxystilbene-2-O-\u03b2-d-glucoside (TSG) on the development of atherosclerotic plaque in ApoE<jats:sup>\u2212\/\u2212<\/jats:sup> mice, and explore the mechanisms involved. Our data showed that after 8 weeks of treatment, TSG ameliorated serum levels of total cholesterol, triglyceride, and low density lipoprotein cholesterol, and increased serum levels of high density lipoprotein cholesterol in ApoE<jats:sup>\u2212\/\u2212<\/jats:sup> mice. TSG suppressed hepatic steatosis, the formation of atherosclerotic lesions, and the formation of macrophage foam cells in ApoE<jats:sup>\u2212\/\u2212<\/jats:sup> mice. Moreover, TSG improved the expressions of hepatic SR-BI, ABCG5, and CYP7A1, and up-regulated the protein expressions of aortic ABCA1 and ABCG1. An in-vitro study showed that TSG promoted macrophage cholesterol efflux and increased the protein expressions of ABCA1 and ABCG1. Our findings provide evidence for a positive role of TSG in preventing atherosclerosis by promoting reverse cholesterol transport. These effects may be achieved by stimulating cholesterol efflux through ABCA1 and ABCG1, promoting SR-BI-mediated cholesterol uptake in the liver, increasing secretion of cholesterol into bile by ABCG5, and improving cholesterol metabolism by the CYP7A1 pathway. In addition, antioxidative and anti-inflammatory effects of TSG may also contribute to its inhibitory effects on atherosclerosis. Further study is needed to investigate whether other potential mechanisms are involved in TSG-mediated atheroprotection. <\/jats:p>","DOI":"10.1139\/cjpp-2017-0474","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T21:35:00Z","timestamp":1504301700000},"page":"8-17","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["2,3,4\u2032,5-tetrahydroxystilbene-2-<i>O<\/i>-\u03b2-<scp>d<\/scp>-glycoside attenuates atherosclerosis in apolipoprotein\u2009E-deficient mice: role of reverse cholesterol transport"],"prefix":"10.1139","volume":"96","author":[{"given":"Xuemeng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Nantong University Pharmacy College, Nantong 226001, China."},{"name":"Department of Pharmacology, Nantong University Pharmacy College, Nantong 226001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Nantong University Pharmacy College, Nantong 226001, China."},{"name":"Department of Pharmacology, Nantong University Pharmacy College, Nantong 226001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Nantong University Pharmacy College, Nantong 226001, China."},{"name":"Department of Pharmacology, Nantong University Pharmacy College, Nantong 226001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoLe","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Nantong University Pharmacy College, Nantong 226001, China."},{"name":"Department of Pharmacology, Nantong University Pharmacy College, Nantong 226001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2010.02.031"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.5604\/17322693.1229823"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050291"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.06.012"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12689"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-09665-0_4"},{"issue":"1","key":"refg7\/ref7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"Folch J.","year":"1957","journal-title":"J. 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