{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:51:52Z","timestamp":1780372312941,"version":"3.54.1"},"reference-count":37,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p> Lycopene is a natural dietary carotenoid that was reported to exhibit a neuroprotective profile. Considering that excitotoxicity and cell death induced by glutamate are involved in many brain disorders, the effect of lycopene on glutamate release in rat cerebrocortical nerve terminals and the possible mechanism involved in such effect was investigated. We observed here that lycopene inhibited 4-aminopyridine (4-AP)-evoked glutamate release and intrasynaptosomal Ca<jats:sup>2+<\/jats:sup> concentration elevation. The inhibitory effect of lycopene on 4-AP-evoked glutamate release was markedly reduced in the presence of the Ca<jats:sub>v<\/jats:sub>2.2 (N-type) and Ca<jats:sub>v<\/jats:sub>2.1 (P\/Q-type) channel blocker \u03c9-conotoxin MVIIC, but was insensitive to the intracellular Ca<jats:sup>2+<\/jats:sup>-release inhibitors dantrolene and CGP37157. Furthermore, in the presence of the protein kinase C inhibitors GF109203X and Go6976, the action of lycopene on evoked glutamate release was prevented. These results are the first to suggest that lycopene inhibits glutamate release from rat cortical synaptosomes by suppressing presynaptic Ca<jats:sup>2+<\/jats:sup> entry and protein kinase C activity. <\/jats:p>","DOI":"10.1139\/cjpp-2017-0520","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T22:34:39Z","timestamp":1512686079000},"page":"479-484","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Lycopene depresses glutamate release through inhibition of voltage-dependent Ca<sup>2+<\/sup> entry and protein kinase C in rat cerebrocortical nerve terminals"],"prefix":"10.1139","volume":"96","author":[{"given":"Cheng-Wei","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 220, Taiwan."},{"name":"Department of Mechanical Engineering, Yuan Ze University, Taoyuan City 320, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Feng","family":"Hung","sequence":"additional","affiliation":[{"name":"School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan."},{"name":"Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Horng","family":"Jean","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 220, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 220, Taiwan."},{"name":"Department of Mechanical Engineering, Yuan Ze University, Taoyuan City 320, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Kuei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 220, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Jane","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan."},{"name":"Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan City 33303, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2012.07844.x"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12310"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5533"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100281"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-142232"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)01061-7"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01955.x"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.3305\/nh.2013.28.1.6302"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-012-0952-5"},{"key":"refg10\/ref10","first-page":"S7","volume":"44","author":"Greenamyre J.T.","year":"1994","journal-title":"Neurology"},{"issue":"6","key":"refg11\/ref11","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","volume":"260","author":"Grynkiewicz G.","year":"1985","journal-title":"J. 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