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Group 2: diabetic non-treated (DNT) rats were injected with streptozotocin (STZ) to get diabetic then after 72 h received oral saline daily. Group 3: rats were injected with STZ then after 72 h were treated with metformin (200 mg\/kg) orally. Group 4: rats were injected with STZ then after 72 h received sitagliptin 6 mg\/kg orally twice daily. Group 5: rats were injected with STZ then after 72 h were treated with liraglutide at a dose of 0.3 mg\/kg every 12 h subcutaneous injection. After 8 weeks, body mass, fasting blood glucose, adipocytokines, and lipid profile were assessed. From the results, we concluded that the 3 drugs improved blood glucose and insulin resistance with correction of adipocytokines serum levels; however, the liraglutide-treated group was the only group that showed significant body mass reduction. <\/jats:p>","DOI":"10.1139\/cjpp-2017-0650","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T21:46:38Z","timestamp":1533332798000},"page":"1226-1231","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Metformin, sitagliptin, and liraglutide modulate serum retinol-binding protein-4 level and adipocytokine production in type 2 diabetes mellitus rat model"],"prefix":"10.1139","volume":"96","author":[{"given":"Noha A.T.","family":"Abbas","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Medicine, Zagazig University, Zagazig, Egypt."},{"name":"Department of Clinical Pharmacology, Faculty of Medicine, Zagazig University, Zagazig, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"El. 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